PMID- 21738271
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20211020
IS  - 1738-0006 (Electronic)
IS  - 0023-4001 (Print)
IS  - 0023-4001 (Linking)
VI  - 49
IP  - 2
DP  - 2011 Jun
TI  - Assessment of loiasis and outcomes of ivermectin masstreatment in Ijebu-North, 
      Nigeria.
PG  - 153-9
LID - 10.3347/kjp.2011.49.2.153 [doi]
AB  - A total of 286 individuals from 3 selected communities (Areedi-Aje, 
      Ipakodo/Ojokodo, and Ijebu-Igbo) of Ijebu-North, southwestern Nigeria were 
      examined for Loa loa microfilaremia using finger prick blood smear, between 
      December 2008 and March 2009. Rapid assessment procedure for loiasis (RAPLOA) was 
      used to obtain information, from 187 Ijebu-Igbo residents, on adverse reactions 
      experienced from retrospective treatments with ivermectin and history of eye 
      worm. Only 33.9% of the respondents reported having had a history of eye worm 
      while 33.2% had microfilaremia. The demographic factor of gender was not 
      significant determinants of the prevalence (P>0.05) while age was significant 
      (P<0.05). The highest prevalence of eye worm history and microfilaremia were 
      recorded in 61-70 and 15-20 years of age categories, respectively. Ijebu-Igbo had 
      27.3% eye worm history, 32.1% microfilaremia, and the highest intensity of 140 
      microfilariae (mf)/ml. Ipakodo area had the highest eye worm history of 54.4% and 
      the highest intensity of 420 mf/ml. Areedi-Aje had the highest occurrence of 
      45.2% microfilaremia and the highest intensity of 460 mf/ml. Predictably, 
      Areedi-Aje and Ipakodo areas were high risk communities. The low intensity of L. 
      loa infection with an insignificant (2.1%; P>0.05) adverse reactions from 187 
      subjects involved in the retrospective ivermectin administration confirmed that 
      ivermectin delivery may be considered safe. The community-directed treatment with 
      ivermectin (CDTI) programme was most probably responsible for the low prevalence 
      and intensity.
FAU - Hassan, A A
AU  - Hassan AA
AD  - Department of Zoology, University of Ibadan, Nigeria. ess_hassan@yahoo.com
FAU - Akinsanya, B
AU  - Akinsanya B
FAU - Iyase, N
AU  - Iyase N
FAU - Owagboriaye, F O
AU  - Owagboriaye FO
LA  - eng
PT  - Journal Article
DEP - 20110614
PL  - Korea (South)
TA  - Korean J Parasitol
JT  - The Korean journal of parasitology
JID - 9435800
RN  - 0 (Filaricides)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Animals
MH  - Female
MH  - Filaricides/*administration & dosage/adverse effects
MH  - Geography
MH  - Humans
MH  - Ivermectin/*administration & dosage/adverse effects
MH  - Loa/drug effects/*isolation & purification
MH  - Loiasis/*drug therapy/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3121072
OTO - NOTNLM
OT  - Loa loa
OT  - Nigeria
OT  - adverse reaction
OT  - ivermectin
OT  - microfilaremia
EDAT- 2011/07/09 06:00
MHDA- 2011/10/26 06:00
PMCR- 2011/06/01
CRDT- 2011/07/09 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2011/03/18 00:00 [revised]
PHST- 2011/03/26 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - 10.3347/kjp.2011.49.2.153 [doi]
PST - ppublish
SO  - Korean J Parasitol. 2011 Jun;49(2):153-9. doi: 10.3347/kjp.2011.49.2.153. Epub 
      2011 Jun 14.