PMID- 21738793
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20231105
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 6
DP  - 2011
TI  - Association pattern of interleukin-1 receptor-associated kinase-4 gene 
      polymorphisms with allergic rhinitis in a Han Chinese population.
PG  - e21769
LID - 10.1371/journal.pone.0021769 [doi]
AB  - OBJECTIVE: Interleukin-1 receptor-associated kinase-4 (IRAK-4) encodes a kinase 
      that is essential for NF-kB activation in Toll-like receptor and T-cell receptor 
      signaling pathways, indicating a possible crosstalk between innate and acquired 
      immunities. We attempted to determine whether the polymorphisms in the 
      Interleukin-1 receptor-associated kinase-4 (IRAK-4) gene are associated with 
      allergic rhinitis (AR) in the Han Chinese population. METHODS: A population of 
      379 patients with AR and 333 healthy controls was studied. Blood was drawn for 
      DNA extraction and total serum immunoglobulin E (IgE). A total of 11 single 
      nucleotide polymorphisms (SNPs) in IRAK-4 were selected and individually 
      genotyped. RESULTS: Significant allelic differences between cases and controls 
      were obtained for the SNP of rs3794262 in the IRAK-4 gene. In the stratified 
      analysis for gender, two SNPs (rs4251431 and rs6582484) in males appeared as 
      significant associations. Subgroup analysis for the presence of different 
      allergen sensitivities displayed associations only in the house dust 
      mite-allergic cohorts (rs3794262, rs4251481). None of the selected SNPs in IRAK-4 
      was associated with total IgE level. The haplotype analysis indicated GCCTGCGA 
      was significantly associated with AR. The SNP-SNP interaction information 
      analysis indicated that the selected sets of polymorphisms had no synergistic 
      effect. CONCLUSIONS: Our findings did not support the potential contribution of 
      the IRAK-4 gene to serum IgE levels. However, the results demonstrated a gender- 
      and allergen-dependant association pattern between polymorphisms in IRAK-4 and AR 
      in Chinese population.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education of 
      China, Beijing Institute of Otorhinolaryngology, Beijing, People's Republic of 
      China.
FAU - Lin, Xiaoping
AU  - Lin X
FAU - Desrosiers, Martin
AU  - Desrosiers M
FAU - Zhang, Wei
AU  - Zhang W
FAU - Meng, Na
AU  - Meng N
FAU - Zhao, Liping
AU  - Zhao L
FAU - Han, Demin
AU  - Han D
FAU - Zhang, Luo
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110630
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-1 Receptor-Associated Kinases/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Rhinitis/*genetics
MH  - Young Adult
PMC - PMC3128076
EDAT- 2011/07/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/09 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - PONE-D-11-02257 [pii]
AID - 10.1371/journal.pone.0021769 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(6):e21769. doi: 10.1371/journal.pone.0021769. Epub 2011 Jun 30.