PMID- 21739309
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220318
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Linking)
VI  - 110
IP  - 2
DP  - 2012 Feb
TI  - Curcumin-loaded into PLGA nanoparticles: preparation and in vitro 
      schistosomicidal activity.
PG  - 593-8
LID - 10.1007/s00436-011-2527-9 [doi]
AB  - The incorporation of the curcumin into poly(lactic-co-glycolic)acid (PLGA) 
      nanospheres by the nanoprecipitation technique, the characterization of the 
      nanoparticles and the schistosomicidal activity of the curcumin-loaded into PLGA 
      nanospheres were reported. The incorporation process occurred with high 
      efficiency and the images of field-emission scanning electron microscopy (FESEM) 
      revealed the production of spherically shaped particles. According to the dynamic 
      light scattering measurements, the particles are nanometric and monodisperse. The 
      curcumin-loaded PLGA nanoparticles (50 and 100 muM) caused the death of all worms 
      and a separation between 50% and 100% of Schistosoma mansoni couples at 
      concentrations from 30 muM. Moreover, the curcumin-loaded PLGA nanoparticles also 
      decreased the motor activity and caused partial alterations in the tegument of 
      adult worms. This study marks the first time that schistosomicidal activity has 
      been reported for curcumin-loaded PLGA nanoparticles.
FAU - Luz, Priscilla P
AU  - Luz PP
AD  - Grupo de Pesquisas em Produtos Naturais, Nucleo de Pesquisas em Ciencias Exatas e 
      Tecnologicas da Universidade de Franca, Franca, 14404-600 SP, Brazil.
FAU - Magalhaes, Lizandra G
AU  - Magalhaes LG
FAU - Pereira, Ana Carolina
AU  - Pereira AC
FAU - Cunha, Wilson R
AU  - Cunha WR
FAU - Rodrigues, Vanderlei
AU  - Rodrigues V
FAU - Andrade E Silva, Marcio L
AU  - Andrade E Silva ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Anthelmintics)
RN  - 0 (Drug Carriers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anthelmintics/pharmacokinetics/*pharmacology
MH  - Curcumin/*pharmacokinetics/pharmacology
MH  - Drug Carriers/*metabolism
MH  - Female
MH  - Humans
MH  - Lactic Acid/*metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Microscopy, Electron
MH  - *Nanoparticles
MH  - Polyglycolic Acid/*metabolism
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Schistosoma mansoni/*drug effects/physiology/ultrastructure
MH  - Survival Analysis
EDAT- 2011/07/09 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/06/08 00:00 [received]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.1007/s00436-011-2527-9 [doi]
PST - ppublish
SO  - Parasitol Res. 2012 Feb;110(2):593-8. doi: 10.1007/s00436-011-2527-9. Epub 2011 
      Jul 8.