PMID- 21740192
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20171116
IS  - 1931-843X (Electronic)
IS  - 1540-9996 (Linking)
VI  - 20
IP  - 9
DP  - 2011 Sep
TI  - Signs and symptoms of suspected myocardial ischemia in women: results from the 
      What is the Optimal Method for Ischemia Evaluation in WomeN? Trial.
PG  - 1261-8
LID - 10.1089/jwh.2010.2595 [doi]
AB  - BACKGROUND: Much of our understanding of gender differences in chest pain was 
      derived from noncontemporary reports. The aim of the current report was to 
      compare the frequency of chest pain by measures of ischemia in 824 women with 
      suspected myocardial ischemia prospectively enrolled in a clinical trial of 
      exercise testing with electrocardiography (ETT-ECG) alone compared to myocardial 
      perfusion single photon emission computed tomography (SPECT) (ETT-MPS). METHODS: 
      Women seeking evaluation of chest pain or anginal equivalent symptoms were 
      randomized to ETT-ECG or ETT-MPS with Tc-99m tetrofosmin. The Women's Ischemia 
      Syndrome Evaluation (WISE) and Seattle Angina Questionnaire (SAQ) chest pain and 
      Duke Activity Status Index (DASI) questionnaires were employed in enrolled women. 
      Higher SAQ scores denote improved symptoms or functioning. RESULTS: Eight hundred 
      twenty-four women, average age 63 years, at intermediate-high coronary artery 
      disease (CAD) likelihood were enrolled from 43 North American centers. 
      Traditional cardiac risk factors were prevalent, with nearly half of women having 
      a family history of premature coronary disease, hypertension, and hyperlipidemia. 
      Chest pain symptoms occurring at least one to three times per week were reported 
      in 60% of women. An examination of the SAQ domains revealed that although women 
      reported minimal physical limitations (median, interquartile range [IQR] 88, 
      75-100), there was a greater frequency of stable chest pain symptoms (median, 
      IQR=40, 30-50). The majority of women (79%) reported moderate to heavy physical 
      activity levels at home, with the average ETT and DASI estimated metabolic 
      equivalents (METs) of 8.6+/-2.6 and 11.5+/-3.8. Women with more frequent daily 
      episodes of chest pain were more likely to have a lower Duke Treadmill Score 
      (DTS), 1 or mm of ST segment depression, and an abnormal MPS. CONCLUSIONS: The 
      current report details a contemporary evaluation of female-specific 
      symptomatology and measures of myocardial ischemia. Women reporting frequent 
      angina were more likely to exhibit ischemia and this may characterize a 
      female-specific typical angina pattern.
FAU - Mieres, Jennifer H
AU  - Mieres JH
AD  - North Shore University Hospital, Manhasset, New York, USA. JMieres@nshs.edu
FAU - Heller, Gary V
AU  - Heller GV
FAU - Hendel, Robert C
AU  - Hendel RC
FAU - Gulati, Martha
AU  - Gulati M
FAU - Boden, William E
AU  - Boden WE
FAU - Katten, Deborah
AU  - Katten D
FAU - Shaw, Leslee J
AU  - Shaw LJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - United States
TA  - J Womens Health (Larchmt)
JT  - Journal of women's health (2002)
JID - 101159262
SB  - IM
MH  - Chest Pain/*epidemiology/etiology
MH  - Coronary Artery Disease/diagnosis
MH  - Diabetes Mellitus/epidemiology
MH  - Echocardiography, Stress
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/epidemiology
MH  - Hypertension/epidemiology
MH  - Metabolic Syndrome/epidemiology
MH  - Middle Aged
MH  - Motor Activity
MH  - Myocardial Ischemia/*diagnosis
MH  - Myocardial Perfusion Imaging/*methods
MH  - North America/epidemiology
MH  - Prospective Studies
MH  - Quality of Life
MH  - *Tomography, Emission-Computed, Single-Photon
MH  - Women's Health
EDAT- 2011/07/12 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1089/jwh.2010.2595 [doi]
PST - ppublish
SO  - J Womens Health (Larchmt). 2011 Sep;20(9):1261-8. doi: 10.1089/jwh.2010.2595. 
      Epub 2011 Jul 8.