PMID- 21740269
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20160511
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 13
IP  - 5
DP  - 2011 Oct
TI  - Changes in the somatotrophic axis in genetically identical dogs.
PG  - 451-7
LID - 10.1089/cell.2011.0023 [doi]
AB  - Because cloned dogs are genetically identical, variations among these animals can 
      be a useful tool to elucidate mechanisms underlying phenotypic differences. To 
      estimate the influence of genetic factors on phenotypic variation, changes in 
      concentration patterns of growth hormone (GH), insulin like growth factor-1 
      (IGF-1), and IGF binding protein 3 (IGFBP-3) were compared among cloned and 
      age-matched control dogs. In addition, the concentrations of GH and IGF-1 
      following administration of growth hormone releasing hormone (GHRH) and 
      somatostatin (SRIF) were measured in both groups. In comparing hormone profiles, 
      the control dogs had larger standard deviations from the means for GH, IGF-1, and 
      IGFBP-3 than the clones. Also, the mean concentration of IGFBP-3 in clones was 
      significantly lower than in the controls between 7 to 12 months of age, whereas 
      the IGFBP-3 changes in clones and controls followed the same pattern. GHRH 
      induced increased serum growth hormone concentration both in clones and controls. 
      However, the concentration of IGF-1 was lower in clones than in controls, and 
      larger standard variations were noted in the control group. In conclusion, the 
      measured traits were more homogeneous in cloned animals than in controls, so 
      cloned animals could be valuable for assessing effects of genotype and 
      environment interactions.
FAU - Park, JungEun
AU  - Park J
AD  - Department of Theriogenology & Biotechnology, College of Veterinary Medicine, 
      Seoul National University, Seoul, Republic of Korea.
FAU - Oh, HyunJu
AU  - Oh H
FAU - Kim, MinJung
AU  - Kim M
FAU - Kim, GeonA
AU  - Kim G
FAU - Park, EunJung
AU  - Park E
FAU - Jang, Goo
AU  - Jang G
FAU - Lee, ByeongChun
AU  - Lee B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - *Cloning, Organism
MH  - Dogs/*blood/genetics
MH  - *Gene-Environment Interaction
MH  - Genotype
MH  - Growth Hormone/*blood/genetics
MH  - Growth Hormone-Releasing Hormone/*blood/genetics
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood/genetics
MH  - Insulin-Like Growth Factor I/genetics/*metabolism
EDAT- 2011/07/12 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1089/cell.2011.0023 [doi]
PST - ppublish
SO  - Cell Reprogram. 2011 Oct;13(5):451-7. doi: 10.1089/cell.2011.0023. Epub 2011 Jul 
      8.