PMID- 21740335 OWN - NLM STAT- MEDLINE DCOM- 20120309 LR - 20211020 IS - 1557-7716 (Electronic) IS - 1523-0864 (Print) IS - 1523-0864 (Linking) VI - 16 IP - 1 DP - 2012 Jan 1 TI - Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis? PG - 85-91 LID - 10.1089/ars.2011.4139 [doi] AB - Maintenance of healthy arteries requires a balance between injuries to the arterial wall and processes of intrinsic arterial repair. Such repair requires the availability of progenitor cells that are local to the wall itself. Progenitor cells from distant reservoirs like the bone marrow may also contribute to repair. Arterial repair seems to degrade over a lifetime, particularly with risk factors such as smoking and diabetes. Hence, a potential preventive/therapeutic strategy for atherosclerosis could be transfusion of competent bone marrow cells (BMCs) to restore effective repair in the face of arterial injury and depleted endogenous repair reservoirs. The challenge with this strategy has been the reliable collection and/or generation of BMCs that support arterial repair. In this study, we describe a set of experiments to elucidate a method of culturing BMCs that robustly retards atherosclerosis development in apolipoprotein E knockout mice. Identifying such a method would represent an important step in developing cell-based treatments for patients with proclivity for developing atherosclerosis. FAU - Song, Xiaohua AU - Song X AD - Division of Cardiology, Department of Medicine, University of Miami, Florida, USA. FAU - Ma, Qi AU - Ma Q FAU - Liu, Xialin AU - Liu X FAU - Seo, Pearl AU - Seo P FAU - Herderick, Ed AU - Herderick E FAU - Webster, Keith AU - Webster K FAU - Goldschmidt-Clermont, Pascal J AU - Goldschmidt-Clermont PJ FAU - Seo, David AU - Seo D LA - eng GR - K12RR17630/RR/NCRR NIH HHS/United States GR - R01 HL71536/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20110922 PL - United States TA - Antioxid Redox Signal JT - Antioxidants & redox signaling JID - 100888899 RN - 0 (Apolipoproteins E) SB - IM MH - Animals MH - Apolipoproteins E/genetics MH - Atherosclerosis/genetics/metabolism/*therapy MH - *Bone Marrow Transplantation MH - Cluster Analysis MH - Disease Models, Animal MH - Gene Expression Profiling MH - Gene Expression Regulation MH - Injections, Intravenous MH - Mice MH - Mice, Inbred C57BL MH - Mice, Knockout MH - Primary Cell Culture/methods MH - Treatment Outcome PMC - PMC3218380 EDAT- 2011/07/12 06:00 MHDA- 2012/03/10 06:00 PMCR- 2013/01/01 CRDT- 2011/07/12 06:00 PHST- 2011/07/12 06:00 [entrez] PHST- 2011/07/12 06:00 [pubmed] PHST- 2012/03/10 06:00 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - 10.1089/ars.2011.4139 [pii] AID - 10.1089/ars.2011.4139 [doi] PST - ppublish SO - Antioxid Redox Signal. 2012 Jan 1;16(1):85-91. doi: 10.1089/ars.2011.4139. Epub 2011 Sep 22.