PMID- 21740494
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110818
IS  - 1462-5822 (Electronic)
IS  - 1462-5814 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Sep
TI  - Dendritic cells in oral tolerance in the gut.
PG  - 1312-8
LID - 10.1111/j.1462-5822.2011.01626.x [doi]
AB  - Oral tolerance is a process that allows generation of systemic unresponsiveness 
      to food antigens. Hence if the same antigen is introduced systemically even under 
      immunogenic conditions it does not induce immune responsiveness. Dendritic cells 
      (DCs) have been identified as essential players in this process. DCs in the gut 
      are located in a strategic position as they can interact directly with luminal 
      antigens or indirectly after their transcytosis across epithelial cells. DCs can 
      then migrate to associated lymphoid tissues to induce tolerance. Antigen 
      presenting cells in the gut are specialized in function and have divided their 
      labour so that there are cells capable to migrate to the draining mesenteric 
      lymph node for induction of T regulatory cells, while other subsets are resident 
      and are required to enforce tolerance locally in the gut after food antigen 
      exposure. In this review, I shall summarize the characteristics of antigen 
      presenting cells in the gut and their involvement in oral tolerance induction. In 
      addition, I will also emphasize that tolerance to food allergens may be 
      contributed by plasmacytoid DCs in the liver that participate to the elimination 
      or anergy of allergen-specific CD8 T cells. Hence specialized functions are 
      associated to different subsets of antigen presenting cells and different organs.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Rescigno, Maria
AU  - Rescigno M
AD  - Department of Experimental Oncology, European Institute of Oncology, Milan, 
      Italy. maria.rescigno@ifom-ieo-campus.it
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110711
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*immunology
MH  - Dendritic Cells/*immunology/physiology
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Immune Tolerance/immunology/physiology
MH  - Immunity, Mucosal/*immunology/physiology
EDAT- 2011/07/12 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1111/j.1462-5822.2011.01626.x [doi]
PST - ppublish
SO  - Cell Microbiol. 2011 Sep;13(9):1312-8. doi: 10.1111/j.1462-5822.2011.01626.x. 
      Epub 2011 Jul 11.