PMID- 21740629
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20221207
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15
IP  - 10
DP  - 2011 Oct
TI  - Transforming growth factor-beta1 polymorphisms and chronic obstructive pulmonary 
      disease: a meta-analysis.
PG  - 1301-7
LID - 10.5588/ijtld.10.0295 [doi]
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex polygenic 
      disease in which gene- environment interactions play a critical role in disease 
      onset and progression. Transforming growth factor-beta 1 (TGF-beta 1) is one of several 
      candidate loci for the pathogenesis of COPD, and is highly polymorphic. 
      OBJECTIVE: To derive a more precise estimation of the relationship between the 
      T869C and C-509T polymorphisms of the TGF-beta 1 gene and COPD, a meta-analysis of 
      11 published case-control studies was performed. METHODS: Ten studies with 1507 
      cases and 2542 controls for T869C polymorphism and six studies with 955 cases and 
      2136 controls for C-509T polymorphism were included. The pooled odds ratios were 
      performed respectively for allele contrasts, additive genetic model, dominant 
      genetic model and recessive genetic model. A subgroup analysis was also performed 
      by ethnicity for T869C polymorphism. RESULTS: With respect to T869C polymorphism, 
      a significant association of TGF-beta 1 gene polymorphism at 869T/C with COPD was 
      observed in the overall analysis (C vs. T: OR 0.82, 95%CI 0.70-0.96, P = 0.01). 
      In the subgroup analysis by ethnicity, significant risks were also found in the 
      Caucasian population for C vs. T (OR 0.77, 95%CI 0.60-0.98, P = 0.03), but not in 
      the Asian population (C vs. T: OR 0.88, 95%CI 0.76-1.03, P = 0.10). With respect 
      to C-509T polymorphism, no significant association with COPD was demonstrated in 
      the overall analysis (T vs. C: OR 0.84, 95%CI 0.68- 1.04, P = 0.11). CONCLUSION: 
      Potentially functional TGF-beta 1 T869C polymorphism may play a low penetrance role 
      in COPD susceptibility in an ethnicity-specific manner.
FAU - Zhang, L
AU  - Zhang L
AD  - School of Health Management, Anhui Medical University, Hefei, Anhui, China.
FAU - Chang, W-W
AU  - Chang WW
FAU - Ding, H
AU  - Ding H
FAU - Su, H
AU  - Su H
FAU - Wang, H-Y
AU  - Wang HY
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20110706
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Linear Models
MH  - Models, Genetic
MH  - Odds Ratio
MH  - Penetrance
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Pulmonary Disease, Chronic Obstructive/ethnology/*genetics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Transforming Growth Factor beta1/*genetics
MH  - White People/genetics
EDAT- 2011/07/12 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - 0295 [pii]
AID - 10.5588/ijtld.10.0295 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Oct;15(10):1301-7. doi: 10.5588/ijtld.10.0295. Epub 
      2011 Jul 6.