PMID- 21740919
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20131121
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 62
IP  - 1
DP  - 2012 Jan
TI  - The role of 5-HT(1)A receptors in fish oil-mediated increased BDNF expression in 
      the rat hippocampus and cortex: a possible antidepressant mechanism.
PG  - 184-91
LID - 10.1016/j.neuropharm.2011.06.017 [doi]
AB  - Epidemiological and dietary studies show that nutritional deficit of omega-3 
      polyunsaturated fatty acids (omega-3 PUFA) is directly related to the prevalence and 
      severity of depression. Supplementation with docosahexaenoic acid (DHA) and 
      eicosapentaenoic acid (EPA) during critical periods of development (pregnancy and 
      lactation) is essential for cortical maturation, synaptogenesis and myelination, 
      and may also mitigate the risk for cognitive deficits and psychopathologies in 
      young adults. The present study was performed to evaluate the involvement of 
      serotonin (5-HT) receptors, particularly of 5-HT(1A), and hippocampal 
      brain-derived neurotrophic factor (BDNF) expression in the antidepressant effect 
      of omega-3 PUFA supplementation. In Experiment 1, the antidepressant effects of fish 
      oil were assessed by the modified forced swim test in adult rats. The data 
      indicated a robust antidepressant effect produced by this supplementation and 
      that treatment of the rats with WAY 100135 reversed this effect. In Experiment 2, 
      cortical and hippocampal contents of BDNF, 5-HT, dopamine (DA) and its 
      metabolites, 5-hydroxyindoleacetic acid (5-HIAA), and 3,4-dihydroxyphenylacetic 
      acid (DOPAC), were determined in animals subjected to the same protocol. 
      Increased BDNF expression in the cortex and hippocampus of both age groups was 
      detected. In 90 day-old rats, 5-HT content in the hippocampus was increased, 
      whereas 5-HIAA formation was diminished in the fish oil group. We suggest the 
      occurrence of a reciprocal involvement of 5-HT(1A) receptors activation and the 
      hippocampal BDNF-increased expression mediated by fish oil supplementation. These 
      data corroborate and expand the notion that supplementation with omega-3 PUFA 
      produces antidepressant effects mediated by an increase in serotonergic 
      neurotransmission, particularly in the hippocampus. This article is part of a 
      Special Issue entitled 'Anxiety and Depression'.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Vines, Aparecida
AU  - Vines A
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990 Curitiba, PR, Brazil.
FAU - Delattre, Ana Marcia
AU  - Delattre AM
FAU - Lima, Marcelo M S
AU  - Lima MM
FAU - Rodrigues, Lais Soares
AU  - Rodrigues LS
FAU - Suchecki, Deborah
AU  - Suchecki D
FAU - Machado, Ricardo B
AU  - Machado RB
FAU - Tufik, Sergio
AU  - Tufik S
FAU - Pereira, Sofia I R
AU  - Pereira SI
FAU - Zanata, Silvio M
AU  - Zanata SM
FAU - Ferraz, Anete Curte
AU  - Ferraz AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110629
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Antagonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 133025-23-7 (WAY 100135)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Depression/*diet therapy/pathology/physiopathology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Female
MH  - Fenclonine/pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Immobility Response, Tonic/drug effects
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neurochemistry
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT1A/*metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Swimming/psychology
EDAT- 2011/07/12 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/04/19 00:00 [received]
PHST- 2011/06/14 00:00 [revised]
PHST- 2011/06/17 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - S0028-3908(11)00261-9 [pii]
AID - 10.1016/j.neuropharm.2011.06.017 [doi]
PST - ppublish
SO  - Neuropharmacology. 2012 Jan;62(1):184-91. doi: 10.1016/j.neuropharm.2011.06.017. 
      Epub 2011 Jun 29.