PMID- 21741664
OWN - NLM
STAT- MEDLINE
DCOM- 20120530
LR  - 20110812
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 308
IP  - 1-2
DP  - 2011 Sep 15
TI  - HLA associations with multiple sclerosis in Greece.
PG  - 28-31
LID - 10.1016/j.jns.2011.06.037 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of 
      the central nervous system originated by a complex interplay of environmental and 
      genetic factors. The association of MS with the human leukocyte antigen (HLA) 
      class II alleles was investigated in MS patients in northwest Greece, in the 
      geographical region of Epirus. OBJECTIVE: Our aim was to estimate the prevalence 
      of the HLA-DRB1*1501, HLA-DQB1*0602 and HLA-DQA1*0102 alleles, consisting the 
      most common susceptibility haplotype in North European and North American 
      Caucasians. METHODS: We studied 126 MS patients and 93 age and sex matched 
      healthy controls. HLA typing was performed by a polymerase chain reaction (PCR) 
      amplification with sequence-specific primers (PCR-SSP) method. RESULTS: We found 
      that HLA-DRB1*1501, HLA-DQB1*0602 and HLA-DQA1*0102 alleles were significantly 
      more frequent among patients (34% versus 11%, p=0.00015; 69% versus 51%, p=0.01; 
      76% versus 55%, p=0.002, respectively). HLA-DRB1*1501, HLA-DQB1*0602, 
      HLA-DQA1*0102 haplotype was significantly more common among patients (p=0.00067). 
      HLA-DRB1*1501 and HLA-DQB1*0602 alleles were more frequently detected in patients 
      with initial symptoms from the brainstem or the cerebellum (p=0.024). No 
      significant correlation was observed among these alleles with sex, disease 
      clinical course, or age at onset. CONCLUSION: This is the first study to 
      investigate genetic susceptibility to MS in Greece. Our results are in line with 
      previous reports in North European and North American patients.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kouri, Ioanna
AU  - Kouri I
AD  - Neurosurgery Institute, Medical School, University of Ioannina, Ioannina, Greece. 
      ioannakouri@yahoo.gr
FAU - Papakonstantinou, Stylianos
AU  - Papakonstantinou S
FAU - Bempes, Vaios
AU  - Bempes V
FAU - Vasiliadis, Haris S
AU  - Vasiliadis HS
FAU - Kyritsis, Athanasios P
AU  - Kyritsis AP
FAU - Pelidou, Sygkliti-Henrietta
AU  - Pelidou SH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Expression Profiling/methods
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies/methods
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Greece/epidemiology
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/epidemiology/*genetics/pathology
MH  - Young Adult
EDAT- 2011/07/12 06:00
MHDA- 2012/05/31 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/06/16 00:00 [revised]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/05/31 06:00 [medline]
AID - S0022-510X(11)00372-8 [pii]
AID - 10.1016/j.jns.2011.06.037 [doi]
PST - ppublish
SO  - J Neurol Sci. 2011 Sep 15;308(1-2):28-31. doi: 10.1016/j.jns.2011.06.037. Epub 
      2011 Jul 8.