PMID- 21742660
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20120206
IS  - 1553-3514 (Electronic)
IS  - 1553-3506 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Dec
TI  - Laparoscopic Nissen-Rossetti fundoplication is a safe and effective treatment for 
      both Acid and bile gastroesophageal reflux in patients poorly responsive to 
      proton pump inhibitor.
PG  - 387-93
LID - 10.1177/1553350611409593 [doi]
AB  - PURPOSE: The aim of this study was to evaluate the effectiveness of laparoscopic 
      Nissen-Rossetti fundoplication in patients with gastroesophageal reflux disease 
      (GERD) poorly responsive to standard dose proton pump inhibitor (PPI) therapy. 
      METHODS: A total of 35 patients (19 women, 16 men, mean age 44.6 +/- 14.01 years) 
      were enrolled. All the patients underwent symptom questionnaires, upper 
      gastrointestinal endoscopy, esophageal manometry, and combined 24-hour esophageal 
      pH and bilirubin monitoring. Following this, the patients with persistent 
      pathological esophageal acid and/or bilirubin exposure underwent laparoscopic 
      antireflux surgery, followed by clinical and instrumental 12-month follow-up. 
      RESULTS: One year after surgery, there was a significant improvement of symptom 
      score, compared with standard PPI dose period (3.54 +/- 1.67 vs 20.8 +/- 10.9, P < 
      .0001; paired t test) and mean percentage total time acid and bile exposure 
      showed a significant decrease (4.9 +/- 2.9 vs 2.03 +/- 0.74 and 8.3 +/- 3.03 vs 0.84 +/- 
      0.56, P < .0001; paired t test). CONCLUSIONS: In patients with GERD poorly 
      responsive to standard PPI dose, laparoscopic Nissen-Rossetti fundoplication 
      appears to be a safe and effective treatment of symptoms, esophageal damage, as 
      well as both acid and bile reflux.
FAU - Brillantino, Antonio
AU  - Brillantino A
AD  - School of Medicine, I Policlinico, Second University of Naples, Naples, Italy. 
      antonio_brillantino@libero.it
FAU - Schettino, Michele
AU  - Schettino M
FAU - Torelli, Francesco
AU  - Torelli F
FAU - Marano, Luigi
AU  - Marano L
FAU - Porfidia, Raffaele
AU  - Porfidia R
FAU - Reda, Gianmarco
AU  - Reda G
FAU - Grassia, Michele
AU  - Grassia M
FAU - Braccio, Bartolomeo
AU  - Braccio B
FAU - Di Martino, Natale
AU  - Di Martino N
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110707
PL  - United States
TA  - Surg Innov
JT  - Surgical innovation
JID - 101233809
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Esophageal pH Monitoring
MH  - Female
MH  - *Fundoplication
MH  - Gastroesophageal Reflux/drug therapy/*surgery
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Recurrence
MH  - Treatment Outcome
EDAT- 2011/07/12 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 1553350611409593 [pii]
AID - 10.1177/1553350611409593 [doi]
PST - ppublish
SO  - Surg Innov. 2011 Dec;18(4):387-93. doi: 10.1177/1553350611409593. Epub 2011 Jul 
      7.