PMID- 21743292
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220423
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Apr
TI  - Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, 
      testosterone and longevity in the Baltimore Longitudinal Study of Aging.
PG  - 153-8
AB  - BACKGROUND AND AIMS: Caloric restriction (CR) is the most robust and reproducible 
      intervention for slowing aging, and maintaining health and vitality in animals. 
      Previous studies found that CR is associated with changes in specific biomarkers 
      in monkeys that were also associated with reduced risk of mortality in healthy 
      men. In this study we examine the association between other potential biomarkers 
      related to CR and extended lifespan in healthy humans. METHODS: Based on the 
      Baltimore Longitudinal Study of Aging, "long-lived" participants who survived to 
      at least 90 years of age (n=41, cases) were compared with "short-lived" 
      participants who died between 72-76 years of age (n=31, controls) in the nested 
      case control study. Circulating levels of ghrelin, insulin, leptin, interleukin 
      6, adiponectin and testosterone were measured from samples collected between the 
      ages 58 to 70 years. Baseline differences between groups were examined with 
      t-test or Wilcoxon test, and mixed effects general linear model was used for a 
      logistic model to differentiate the two groups with multiple measurements on some 
      subjects. RESULTS: At the time of biomarkers evaluation (58-70 yrs), none of the 
      single biomarker levels was significantly different between the two groups. 
      However, after combining information from multiple biomarkers by adding the 
      z-transformed values, the global score differentiated the long- and short-lived 
      participants (p=0.05). CONCLUSIONS: In their sixties, long-lived and short-lived 
      individuals do not differ in biomarkers that have been associated with CR in 
      animals. However, difference between the groups was only obtained when multiple 
      biomarker dysregulation was considered.
FAU - Stenholm, Sari
AU  - Stenholm S
AD  - National Institute on Aging, Clinical Research Branch, Longitudinal Studies 
      Section, Baltimore, MD 21225, USA.
FAU - Metter, E Jeffrey
AU  - Metter EJ
FAU - Roth, George S
AU  - Roth GS
FAU - Ingram, Donald K
AU  - Ingram DK
FAU - Mattison, Julie A
AU  - Mattison JA
FAU - Taub, Dennis D
AU  - Taub DD
FAU - Ferrucci, Luigi
AU  - Ferrucci L
LA  - eng
GR  - Z01 AG000015/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Ghrelin)
RN  - 0 (IL6 protein, human)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adiponectin/blood
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*blood
MH  - Baltimore
MH  - Biomarkers/blood
MH  - Caloric Restriction
MH  - Case-Control Studies
MH  - Ghrelin/blood
MH  - Humans
MH  - Insulin/blood
MH  - Interleukin-6/blood
MH  - Leptin/blood
MH  - Longevity/*physiology
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Testosterone/blood
PMC - PMC3180822
MID - NIHMS320789
EDAT- 2011/07/12 06:00
MHDA- 2011/08/31 06:00
PMCR- 2011/09/27
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PHST- 2011/09/27 00:00 [pmc-release]
AID - 7836 [pii]
AID - 10.1007/BF03351078 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2011 Apr;23(2):153-8. doi: 10.1007/BF03351078.