PMID- 21743387
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110804
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 92
IP  - 4
DP  - 2011 Aug 27
TI  - Deleterious impact of mismatching for human leukocyte antigen-C in presensitized 
      recipients of kidney transplants.
PG  - 419-25
LID - 10.1097/TP.0b013e318224c14e [doi]
AB  - BACKGROUND: Allocation of deceased donor kidneys is commonly based on matching 
      for human leukocyte antigen (HLA)-A, -B, and -DR, whereas HLA-C is currently 
      disregarded. We investigated the influence of HLA-C compatibility on renal 
      allograft survival. In addition, we tested an approach of matching for HLA-C 
      epitopes. METHODS: A cohort of 2260 deceased donor kidney transplants were typed 
      for HLA-C using polymerase chain reaction-sequence specific primer method. 
      Samples for DNA typing, serum results on presensitization (lymphocytotoxicity), 
      and clinical data were provided by transplant centers participating in the 
      Collaborative Transplant Study. RESULTS: HLA-C mismatch was found to be 
      associated with significantly decreased graft survival in presensitized (P<0.001) 
      but not in non-presensitized (P=0.75) recipients. Mismatch of certain HLA-C 
      epitopes seemed to be more influential than others, with mismatches showing a 
      negative impact on graft survival in presensitized patients. CONCLUSIONS: HLA-C 
      mismatch has a substantial deleterious effect on graft survival in presensitized 
      kidney recipients. Our study points out the need for investigations directed at 
      identifying donor-specific HLA-C antibodies and evaluating their relevance in 
      transplantation. In view of the fact that current assays for determining HLA-C 
      specific antibodies are hampered by additional detection of clinically irrelevant 
      antibodies, matching for HLA-C may provide a reasonable approach to improve 
      transplant outcomes in presensitized kidney transplant recipients.
FAU - Tran, Thuong Hien
AU  - Tran TH
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany. hien.tran@med.uni-heidelberg.de
FAU - Dohler, Bernd
AU  - Dohler B
FAU - Heinold, Andreas
AU  - Heinold A
FAU - Scherer, Sabine
AU  - Scherer S
FAU - Ruhenstroth, Andrea
AU  - Ruhenstroth A
FAU - Opelz, Gerhard
AU  - Opelz G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Epitopes)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Cadaver
MH  - Epitopes/genetics
MH  - Female
MH  - Graft Survival/genetics/immunology
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - *HLA-C Antigens/genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/blood
MH  - Kidney Transplantation/*adverse effects/*immunology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Tissue Donors
EDAT- 2011/07/12 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1097/TP.0b013e318224c14e [doi]
PST - ppublish
SO  - Transplantation. 2011 Aug 27;92(4):419-25. doi: 10.1097/TP.0b013e318224c14e.