PMID- 2174402
OWN - NLM
STAT- MEDLINE
DCOM- 19910116
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 21
IP  - 12
DP  - 1990 Dec
TI  - Benign nodal lesions mimicking metastases from pediatric renal neoplasms: a 
      report of the National Wilms' Tumor Study Pathology Center.
PG  - 1239-44
AB  - Regional lymph node status is a key factor in the staging of pediatric renal 
      tumors on the National Wilms' Tumor Study (NWTS). A review of cases entered on 
      the NWTS has uncovered a number of cases where benign lymph node findings were 
      mistaken for metastases. Most frequently, this was due to the presence of 
      complexes of epithelial cells and Tamm-Horsfall protein within nodal sinuses. The 
      epithelial cells were derived from damaged nephrons, usually resulting from 
      obstruction by tumor. Another epithelial pseudometastic lesion, intranodal 
      squamous epithelial cells, was found to originate from metaplastic calyceal 
      urothelium. Benign mesothelial or coelomic inclusions similar to those previously 
      described in pelvic and periaortic lymph nodes of adult females were found in 
      nodes of four patients, including two boys, who are, to our knowledge, the first 
      to be described with this finding. Other sources of confusion included protrusion 
      of lymphoid follicles or germinal centers into nodal sinuses, thick endothelial 
      cells of postcapillary venules mimicking epithelial tubules, nodal megakaryocytes 
      resembling anaplastic nuclear changes, and histiocytic granulomas. 
      Immunocytochemical methods were useful in evaluating some of these phenomena. 
      Recognition of these pseudometastatic lesions is essential in order to avoid 
      unnecessary and potentially hazardous therapeutic intensification.
FAU - Weeks, D A
AU  - Weeks DA
AD  - Department of Pathology, Children's Hospital, Denver, CO 80218.
FAU - Beckwith, J B
AU  - Beckwith JB
FAU - Mierau, G W
AU  - Mierau GW
LA  - eng
GR  - CA 42326/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Epithelium/pathology
MH  - Humans
MH  - Inclusion Bodies/pathology
MH  - Infant
MH  - Kidney Neoplasms/*pathology
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis/*pathology
MH  - Wilms Tumor/*pathology/secondary
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - S0046-8177(06)80037-7 [pii]
AID - 10.1016/s0046-8177(06)80037-7 [doi]
PST - ppublish
SO  - Hum Pathol. 1990 Dec;21(12):1239-44. doi: 10.1016/s0046-8177(06)80037-7.