PMID- 21744232
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20211020
IS  - 1352-8661 (Electronic)
IS  - 0968-5243 (Linking)
VI  - 24
IP  - 5
DP  - 2011 Oct
TI  - MR spectroscopy as a tool for in vivo determination of steatosis in liver 
      transplant recipients.
PG  - 297-304
LID - 10.1007/s10334-011-0264-9 [doi]
AB  - OBJECT: Among several non-invasive methods of liver fat analysis, the most 
      important role is played by MR imaging and spectroscopy (MRS). This study 
      describes the 1H MRS at 3T measurement of liver fat volume fraction Phi(fat) in a 
      group of liver transplant patients, an at-risk group for the development of de 
      novo steatosis. MATERIALS AND METHODS: Seventy-seven liver transplant recipients 
      who underwent routine protocolar posttransplant examination were divided into 
      three groups: CON-PAT (control group for the cross validation test, 48 patients), 
      PAT-PAT (patients test group for the cross validation test, 29 patients), and PAT 
      (pooled data). Single voxel 1H MRS at 3T was used for the determination of Phi(fat) 
      and histology results (His) were used as the reference standard. RESULTS: Linear 
      and non-linear regression models were used to describe the relationship between 
      Phi(fat) and His. Strong correlation was found for both models with r = 0.83-0.94 
      (P < 0.001); a higher r was found for non-linear regression in all tested groups. 
      Areas under receiver operation curves were calculated for cut points His >/= 5 and 
      > 33% and were found in the range of 0.77-0.86. Fibrosis influences the 
      calculation of Phi(fat) and different slopes were obtained for fibrosis stages 
      F0-F1 and F2-F3, respectively. CONCLUSION: Significant correlation was found 
      between the results of histology and 1H MRS measurement of liver fat content. The 
      method is suitable for non-invasive repetitive examination of liver fat in 
      liver-transplants patients between protocol biopsies and for the screening of 
      steatosis in other liver diseases.
FAU - Hajek, Milan
AU  - Hajek M
AD  - MR spectroscopy, Department of Diagnostic and Interventional Radiology, Institute 
      for Clinical and Experimental Medicine, 140 21, Prague 4, Czech Republic. 
      miha@medicon.cz
FAU - Dezortova, Monika
AU  - Dezortova M
FAU - Wagnerova, Dita
AU  - Wagnerova D
FAU - Skoch, Antonin
AU  - Skoch A
FAU - Voska, Ludek
AU  - Voska L
FAU - Hejlova, Irena
AU  - Hejlova I
FAU - Trunecka, Pavel
AU  - Trunecka P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110710
PL  - Germany
TA  - MAGMA
JT  - Magma (New York, N.Y.)
JID - 9310752
RN  - 0 (Lipids)
RN  - AR09D82C7G (Deuterium)
SB  - IM
MH  - Adipose Tissue/*chemistry
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Deuterium
MH  - Fatty Liver/*diagnosis/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Lipids/biosynthesis
MH  - Liver/*chemistry/*pathology/physiopathology
MH  - Liver Transplantation/*methods
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Nonlinear Dynamics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2011/07/12 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/06/03 00:00 [revised]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - 10.1007/s10334-011-0264-9 [doi]
PST - ppublish
SO  - MAGMA. 2011 Oct;24(5):297-304. doi: 10.1007/s10334-011-0264-9. Epub 2011 Jul 10.