PMID- 21744293
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20231214
IS  - 1880-6562 (Electronic)
IS  - 1880-6546 (Print)
IS  - 1880-6546 (Linking)
VI  - 61
IP  - 5
DP  - 2011 Sep
TI  - Heat acclimation-induced changes in heart glycogen/glucose metabolism in rats.
PG  - 395-402
LID - 10.1007/s12576-011-0162-y [doi]
AB  - Based on the observation that heat acclimation is a slowly developing response, 
      evoked by continuous exposure to moderate heat, we investigated the 
      time-dependent acclimatory changes of heart glycogen metabolism. Cardiac levels 
      of key carbohydrate-related enzymes and substrates were studied in the function 
      of the duration of short-term (STHA; 6, 12, 24 and 48 h) and long-term heat 
      acclimation (LTHA; 7, 14, 21 and 30 days) to high environmental temperature (35 +/- 
      1 degrees C). The changes in heart glycogen metabolism during STHA could be separated in 
      two phases: up to 12 h exposure, where significant decrease of the heart glycogen 
      (Glk), glucose-6-phosphate (G6P), hexokinase (HK) activity as well as increase of 
      heart glucose was observed; and from 24 to 48 h exposure, manifested with 
      elevation of Glk, Glu, glycogen phosphorylase a (GPa), phosphofructokinase (PFK) 
      and HK activities. The metabolic changes in the period of LTHA could also be seen 
      as separate phases: in a period of 7-14 days of heat exposure there was an 
      increase of heart Glk, Glu, G6P, HK, as well as a decrease of GPa and PFK, while 
      in the period of 21-28 days there was more intensive rebound of Glk and G6P, 
      increase of GPa activity and non-significant changes of Glu, HK and PFK. The 
      results obtained have showed that acclimation to moderate hyperthermic 
      environment has caused significant changes in examined parameters which differ 
      depending on duration to the exposure: intensive stress-induced glycogenolytic 
      and glycolytic processes in the period of STHA and intensive energy sparing, 
      manifested by Glk deposition in the period of LTHA.
FAU - Dervisevik, Mirsada
AU  - Dervisevik M
AD  - Department of Physiology and Biochemistry, Institute of Biology, Faculty of 
      Natural Sciences and Mathematics, University St Cyrilus and Methodius, Gazi Baba 
      bb, 1 000 Skopje, Republic of Macedonia. mirsadadervisevik@yahoo.com
FAU - Dinevska-Kjovkarovska, Suzana
AU  - Dinevska-Kjovkarovska S
FAU - Miova, Biljana
AU  - Miova B
FAU - Mitev, Slavco
AU  - Mitev S
FAU - Velkovski, Marjan
AU  - Velkovski M
FAU - Susleski, Damjan
AU  - Susleski D
LA  - eng
PT  - Journal Article
DEP - 20110710
PL  - Japan
TA  - J Physiol Sci
JT  - The journal of physiological sciences : JPS
JID - 101262417
RN  - 56-73-5 (Glucose-6-Phosphate)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.4.1.- (Glycogen Phosphorylase)
RN  - EC 2.7.1 - (Phosphofructokinases)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Acclimatization/*physiology
MH  - Animals
MH  - Glucose/*metabolism
MH  - Glucose-6-Phosphate/metabolism
MH  - Glycogen/*metabolism
MH  - Glycogen Phosphorylase/metabolism
MH  - Hexokinase/metabolism
MH  - *Hot Temperature
MH  - Male
MH  - Myocardium/chemistry/*metabolism
MH  - Phosphofructokinases/metabolism
MH  - Rats
MH  - Rats, Wistar
PMC - PMC10717974
EDAT- 2011/07/12 06:00
MHDA- 2012/01/17 06:00
PMCR- 2011/07/10
CRDT- 2011/07/12 06:00
PHST- 2011/03/05 00:00 [received]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
PHST- 2011/07/10 00:00 [pmc-release]
AID - 162 [pii]
AID - 10.1007/s12576-011-0162-y [doi]
PST - ppublish
SO  - J Physiol Sci. 2011 Sep;61(5):395-402. doi: 10.1007/s12576-011-0162-y. Epub 2011 
      Jul 10.