PMID- 21745165
OWN - NLM
STAT- MEDLINE
DCOM- 20120713
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 52
IP  - 12
DP  - 2011 Dec
TI  - Thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid 
      tissue: a clinicopathological and genetic analysis of six cases.
PG  - 2276-83
LID - 10.3109/10428194.2011.596968 [doi]
AB  - We investigated six new cases of primary thymic extranodal marginal zone B-cell 
      lymphoma of mucosa-associated lymphoid tissue (MALT) to further characterize the 
      clinicopathological and genetic features. The male to female ratio was 1:1. One 
      female patient had suffered from systemic lupus erythematosus. Another female 
      patient was diagnosed with rheumatoid arthritis after thymectomy. One patient had 
      a concurrent tumor in the eyelid. Radiologically, all tumors were located in the 
      prevascular space and presented as asymmetric heterogeneously enhanced cystic and 
      solid masses. MALT1, BCL10 or IGH translocations and trisomy 18 were not observed 
      in any cases by fluorescence in situ hybridization (FISH) analysis. Trisomy 3 was 
      detected in one patient and another showed a TNFAIP3/A20 deletion. Meta-analysis 
      (n = 51) including the present and previously reported cases revealed that the 
      prevalence of autoimmunity was much lower in males with thymic MALT lymphoma 
      compared to females (33% vs. 87%, p = 0.001). Additionally, the average age of 
      females or patients with autoimmunity was about 10 years younger than that of 
      males or patients without autoimmunity (p = 0.003 and p = 0.008, respectively). 
      In summary, thymic MALT lymphoma arising without underlying autoimmunity 
      frequently involves males or older patients. Trisomy 3 and an A20 deletion might 
      play a role in the pathogenesis of thymic MALT lymphoma.
FAU - Go, Heounjeong
AU  - Go H
AD  - Department of Pathology, Cancer Research Institute, Seoul National University 
      College of Medicine, Seoul, South Korea.
FAU - Cho, Hwa Jin
AU  - Cho HJ
FAU - Paik, Jin Ho
AU  - Paik JH
FAU - Park, Chang Min
AU  - Park CM
FAU - Oh, Young-Ha
AU  - Oh YH
FAU - Jung, Kyeong Cheon
AU  - Jung KC
FAU - Kim, Chul Woo
AU  - Kim CW
FAU - Jeon, Yoon Kyung
AU  - Jeon YK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110712
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - EC 3.4.19.12 (TNFAIP3 protein, human)
RN  - EC 3.4.19.12 (Tumor Necrosis Factor alpha-Induced Protein 3)
SB  - IM
MH  - Aged
MH  - Chromosomes, Human, Pair 3
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Gene Deletion
MH  - Heterozygote
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics
MH  - Lymphoma, B-Cell, Marginal Zone/*diagnosis/*genetics
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Middle Aged
MH  - Nuclear Proteins/genetics
MH  - Thymus Neoplasms/*diagnosis/*genetics
MH  - Trisomy
MH  - Tumor Necrosis Factor alpha-Induced Protein 3
EDAT- 2011/07/13 06:00
MHDA- 2012/07/14 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/07/14 06:00 [medline]
AID - 10.3109/10428194.2011.596968 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2011 Dec;52(12):2276-83. doi: 10.3109/10428194.2011.596968. Epub 
      2011 Jul 12.