PMID- 21746788
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20211020
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 589
IP  - 17
DP  - 2011 Sep 1
TI  - Enhanced high-frequency membrane potential fluctuations control spike output in 
      striatal fast-spiking interneurones in vivo.
PG  - 4365-81
LID - 10.1113/jphysiol.2011.212944 [doi]
AB  - Fast-spiking interneurones (FSIs) constitute a prominent part of the inhibitory 
      microcircuitry of the striatum; however, little is known about their recruitment 
      by synaptic inputs in vivo. Here, we report that, in contrast to cholinergic 
      interneurones (CINs), FSIs (n = 9) recorded in urethane-anaesthetized rats 
      exhibit Down-to-Up state transitions very similar to spiny projection neurones 
      (SPNs). Compared to SPNs, the FSI Up state membrane potential was noisier and 
      power spectra exhibited significantly larger power at frequencies in the gamma 
      range (55-95 Hz). The membrane potential exhibited short and steep trajectories 
      preceding spontaneous spike discharge, suggesting that fast input components 
      controlled spike output in FSIs. Spontaneous spike data contained a high 
      proportion (43.6 +/- 32.8%) of small inter-spike intervals (ISIs) of <30 ms, 
      setting FSIs clearly apart from SPNs and CINs. Cortical-evoked inputs had slower 
      dynamics in SPNs than FSIs, and repetitive stimulation entrained SPN spike output 
      only if the stimulation was delivered at an intermediate frequency (20 Hz), but 
      not at a high frequency (100 Hz). Pharmacological induction of an activated ECoG 
      state, known to promote rapid FSI spiking, mildly increased the power (by 43 +/- 
      55%, n = 13) at gamma frequencies in the membrane potential of SPNs, but resulted 
      in few small ISIs (<30 ms; 4.3 +/- 6.4%, n = 8). The gamma frequency content did 
      not change in CINs (n = 8). These results indicate that FSIs are uniquely 
      responsive to high-frequency input sequences. By controlling the spike output of 
      SPNs, FSIs could serve gating of top-down signals and long-range synchronisation 
      of gamma-oscillations during behaviour.
FAU - Schulz, Jan M
AU  - Schulz JM
AD  - J. M. Schulz: Department of Physiology, University of Bern, Buhlplatz 5, 3012 
      Bern, Switzerland. schulz@pyl.unibe.ch.
FAU - Pitcher, Toni L
AU  - Pitcher TL
FAU - Savanthrapadian, Shakuntala
AU  - Savanthrapadian S
FAU - Wickens, Jeffery R
AU  - Wickens JR
FAU - Oswald, Manfred J
AU  - Oswald MJ
FAU - Reynolds, John N J
AU  - Reynolds JN
LA  - eng
PT  - Journal Article
DEP - 20110711
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Corpus Striatum
MH  - *Interneurons
MH  - *Membrane Potentials
MH  - Neostriatum
MH  - Neurons
PMC - PMC3180588
EDAT- 2011/07/13 06:00
MHDA- 2016/04/23 06:00
PMCR- 2012/09/01
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - jphysiol.2011.212944 [pii]
AID - 10.1113/jphysiol.2011.212944 [doi]
PST - ppublish
SO  - J Physiol. 2011 Sep 1;589(17):4365-81. doi: 10.1113/jphysiol.2011.212944. Epub 
      2011 Jul 11.