PMID- 21746789
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20211020
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 589
IP  - 17
DP  - 2011 Sep 1
TI  - Activation of beta-adrenergic receptors facilitates heterosynaptic 
      translation-dependent long-term potentiation.
PG  - 4321-40
LID - 10.1113/jphysiol.2011.209379 [doi]
AB  - Noradrenaline critically modulates the ability of synapses to undergo long-term 
      plasticity on time scales extending well beyond fast synaptic transmission. 
      Noradrenergic signalling through beta-adrenergic receptors (beta-ARs) enhances memory 
      consolidation and can boost the longevity of long-term potentiation (LTP). 
      Previous research has shown that stimulation of one synaptic pathway with a 
      protocol that induces persistent, translation-dependent LTP can enable the 
      induction of LTP by subthreshold stimulation at a second, independent synaptic 
      pathway. This heterosynaptic facilitation depends on the regulation and synthesis 
      of proteins. Recordings taken from area CA1 in mouse hippocampal slices showed 
      that induction of beta-AR-dependent LTP at one synaptic pathway (S1) can facilitate 
      LTP at a second, independent pathway (S2) when low-frequency, subthreshold 
      stimulation is applied after a 30 min delay. beta-AR-dependent heterosynaptic 
      facilitation requires protein synthesis as inhibition of mammalian target of 
      rapamycin (mTOR), extracellular signal-regulated kinase (ERK), or translation, 
      prevented homo- and heterosynaptic LTP. Shifting application of a translational 
      repressor, emetine, to coincide with S2 stimulation did not block LTP. 
      Heterosynaptic LTP was prevented in the presence of the cell-permeable 
      cAMP-dependent protein kinase inhibitor, PKI. Conversely, the time window for 
      inter-pathway transfer of heterosynaptic LTP was extended through inhibition of 
      GluR2 endocytosis. Our data show that activation of beta-ARs boosts the 
      heterosynaptic expression of translation-dependent LTP. These results suggest 
      that engagement of the noradrenergic system may extend the associative capacity 
      of hippocampal synapses through facilitation of intersynaptic crosstalk.
FAU - Connor, Steven A
AU  - Connor SA
AD  - Centre for Neuroscience, University of Alberta School of Medicine, Medical 
      Sciences Building, Edmonton, Canada.
FAU - Wang, Yu Tian
AU  - Wang YT
FAU - Nguyen, Peter V
AU  - Nguyen PV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110711
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Receptors, Adrenergic, beta)
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Hippocampus
MH  - *Long-Term Potentiation
MH  - Mice, Inbred C57BL
MH  - *Receptors, Adrenergic, beta
PMC - PMC3180585
EDAT- 2011/07/13 06:00
MHDA- 2016/04/23 06:00
PMCR- 2012/09/01
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - jphysiol.2011.209379 [pii]
AID - 10.1113/jphysiol.2011.209379 [doi]
PST - ppublish
SO  - J Physiol. 2011 Sep 1;589(17):4321-40. doi: 10.1113/jphysiol.2011.209379. Epub 
      2011 Jul 11.