PMID- 21747772
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 2
DP  - 2011
TI  - Changes in maternal gene expression in olfactory circuits in the immediate 
      postpartum period.
PG  - 40
LID - 10.3389/fpsyt.2011.00040 [doi]
LID - 40
AB  - Regulation of maternal behavior in the immediate postpartum period involves 
      neural circuits in reward and homeostasis systems responding to cues from the 
      newborn. Our aim was to assess one specific regulatory mechanism: the role that 
      olfaction plays in the onset and modulation of parenting behavior. We focused on 
      changes in gene expression in olfactory brain regions, examining nine genes found 
      in previous knockout studies to be necessary for maternal behavior. Using a 
      quantitative PCR (qPCR)-based approach, we assessed changes in gene expression in 
      response to exposure to pups in 11 microdissected olfactory brain regions. Over 
      the first postpartum days, all nine genes were detected in all 11 regions (at 
      differing levels) and their expression changed in response to pup exposure. As a 
      general trend, five genes (Dbh, Esr1, FosB, Foxb1, and Oxtr) were found to 
      decrease their expression in most of the olfactory regions examined, while two 
      genes (Mest and Prlr) were found to increase expression. Nos1 and Peg3 levels 
      remained relatively stable except in the accessory olfactory bulb (AOB), where 
      greater than fourfold increases in expression were observed. The largest 
      magnitude expression changes in this study were found in the AOB, which mediates 
      a variety of olfactory cues that elicit stereotypic behaviors such as mating and 
      aggression as well as some non-pheromone odors. Previous analyses of null mice 
      for the nine genes assessed here have rarely examined olfactory function. Our 
      data suggest that there may be olfactory effects in these null mice which 
      contribute to the observed maternal behavioral phenotypes. Collectively, these 
      data support the hypothesis that olfactory processing is an important sensory 
      regulator of maternal behavior.
FAU - Canavan, Sofija V
AU  - Canavan SV
AD  - Department of Neurosurgery, Yale University School of Medicine New Haven, CT, 
      USA.
FAU - Mayes, Linda C
AU  - Mayes LC
FAU - Treloar, Helen B
AU  - Treloar HB
LA  - eng
GR  - P01 DA022446/DA/NIDA NIH HHS/United States
GR  - R01 DA026437/DA/NIDA NIH HHS/United States
GR  - R01 DC007600/DC/NIDCD NIH HHS/United States
GR  - UL1 RR024139/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20110701
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC3130163
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - amygdala
OT  - entorhinal cortex
OT  - hippocampus
OT  - olfactory bulb
OT  - olfactory tubercle
OT  - piriform cortex
EDAT- 2011/07/13 06:00
MHDA- 2011/07/13 06:01
PMCR- 2011/07/01
CRDT- 2011/07/13 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/07/13 06:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.3389/fpsyt.2011.00040 [doi]
PST - epublish
SO  - Front Psychiatry. 2011 Jul 1;2:40. doi: 10.3389/fpsyt.2011.00040. eCollection 
      2011.