PMID- 21747864
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9791 (Electronic)
IS  - 1687-9783 (Print)
IS  - 1687-9783 (Linking)
VI  - 2011
DP  - 2011
TI  - Allergic Potential and Immunotoxicity Induced by Topical Application of 
      1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model.
PG  - 238513
LID - 10.1155/2011/238513 [doi]
LID - 238513
AB  - The purpose of the studies in this paper was to evaluate the allergic potential, 
      immunotoxicity, and irritancy of the occupationally relevant chemical, 
      1-chloro-4-(trifluoromethyl)benzene, also known as parachlorobenzotrifluoride 
      (PCBTF), following dermal exposure in a murine model. Evaluation of the 
      sensitization potential, conducted using the local lymph node assay (LLNA) at 
      concentrations ranging from 50% to 100%, identified a dose-dependent increase in 
      lymphocyte proliferation with a calculated EC3 value of 53.1%. While no 
      elevations in total or specific IgE were observed after exposure to any 
      concentration of the chemical, significant increases in IFN-gamma protein production 
      by stimulated draining lymphoid cells were observed, indicating a T-cell-mediated 
      response. Dermal exposure to PCBTF was not found to alter the immune response to 
      a T-cell-dependant antigen. These results demonstrate that PCBTF has the 
      potential to induce allergic sensitization following dermal exposure and based on 
      LLNA results would be classified as a weak sensitizer.
FAU - Franko, Jennifer
AU  - Franko J
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety 
      and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505-2888, USA.
FAU - Jackson, Laurel G
AU  - Jackson LG
FAU - Meade, B Jean
AU  - Meade BJ
FAU - Anderson, Stacey E
AU  - Anderson SE
LA  - eng
PT  - Journal Article
DEP - 20110514
PL  - United States
TA  - J Allergy (Cairo)
JT  - Journal of allergy
JID - 101535174
PMC - PMC3124874
EDAT- 2011/07/13 06:00
MHDA- 2011/07/13 06:01
PMCR- 2011/05/14
CRDT- 2011/07/13 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/03/11 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/07/13 06:01 [medline]
PHST- 2011/05/14 00:00 [pmc-release]
AID - 10.1155/2011/238513 [doi]
PST - ppublish
SO  - J Allergy (Cairo). 2011;2011:238513. doi: 10.1155/2011/238513. Epub 2011 May 14.