PMID- 21747867
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220311
IS  - 1687-9791 (Electronic)
IS  - 1687-9783 (Print)
IS  - 1687-9783 (Linking)
VI  - 2011
DP  - 2011
TI  - The LLNA: A Brief Review of Recent Advances and Limitations.
PG  - 424203
LID - 10.1155/2011/424203 [doi]
LID - 424203
AB  - Allergic contact dermatitis is the second most commonly reported occupational 
      illness, accounting for 10% to 15% of all occupational diseases. This highlights 
      the importance of developing rapid and sensitive methods for hazard 
      identification of chemical sensitizers. The murine local lymph node assay (LLNA) 
      was developed and validated for the identification of low molecular weight 
      sensitizing chemicals. It provides several benefits over other tests for 
      sensitization because it provides a quantitative endpoint, dose-responsive data, 
      and allows for prediction of potency. However, there are also several concerns 
      with this assay including: levels of false positive responses, variability due to 
      vehicle, and predictivity. This report serves as a concise review which briefly 
      summarizes the progress, advances and limitations of the assay over the last 
      decade.
FAU - Anderson, Stacey E
AU  - Anderson SE
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety 
      and Health, 1095 Willowdale Drive, Morgantown, WV 26505, USA.
FAU - Siegel, Paul D
AU  - Siegel PD
FAU - Meade, B J
AU  - Meade BJ
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - United States
TA  - J Allergy (Cairo)
JT  - Journal of allergy
JID - 101535174
PMC - PMC3124934
EDAT- 2011/07/13 06:00
MHDA- 2011/07/13 06:01
PMCR- 2011/06/16
CRDT- 2011/07/13 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/07/13 06:01 [medline]
PHST- 2011/06/16 00:00 [pmc-release]
AID - 10.1155/2011/424203 [doi]
PST - ppublish
SO  - J Allergy (Cairo). 2011;2011:424203. doi: 10.1155/2011/424203. Epub 2011 Jun 16.