PMID- 21749227
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20191210
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 28
IP  - 10
DP  - 2011 Oct
TI  - Direct analysis of dithiocarbamate fungicides in fruit by ambient mass 
      spectrometry.
PG  - 1372-82
LID - 10.1080/19440049.2011.590456 [doi]
AB  - Dithiocarbamates (DTCs) are fungicides that require a specific single-residue 
      method for detection and verification of compliance with maximum residue limits 
      (MRLs) as established for fruit and vegetables in the EU. In this study, the use 
      of ambient mass spectrometry was investigated for specific determination of 
      individual DTCs (thiram, ziram) in fruit. Two complementary approaches have been 
      investigated for their rapid analysis: (i) direct analysis in real time (DART) 
      combined with medium-high resolution/accurate mass time-of-flight mass 
      spectrometry (TOFMS) and high-resolution/accurate mass Orbitrap MS, and (ii) 
      desorption electrospray ionization (DESI) combined with tandem-in-time mass 
      spectrometry (MS(2)). With both techniques, thiram deposited on a glass surface 
      (DART) or Teflon (DESI) could be directly detected. With DART, this was also 
      possible for ziram. Before the instrumental analysis of fruit matrix, an extract 
      had to be prepared following a straightforward procedure. The raw extracts were 
      deposited on a slide (DESI), or rods were dipped into the extracts (DART), after 
      which thiram and ziram could be rapidly detected (typically 10 samples in a few 
      minutes). In the case of thiram, the lowest calibration levels were 1 mg kg(-1) 
      (DART-TOFMS, DESI-MS(2)) and 0.1 mg kg(-1) (DART-Orbitrap MS). For ziram, the 
      achieved lowest calibration levels were 0.5 mg kg(-1) (DART-TOFMS) and 
      1 mg kg(-1) (DART-Orbitrap MS). In all cases, this was sufficiently low to test 
      samples against EU-MRLs for a number of fruit crops. Using an internal standard, 
      (semi)quantitative results could be obtained.
FAU - Cajka, Tomas
AU  - Cajka T
AD  - Department of Food Chemistry and Analysis, Faculty of Food and Biochemical 
      Technology, Institute of Chemical Technology Prague, Prague, Czech Republic.
FAU - Riddellova, Katerina
AU  - Riddellova K
FAU - Zomer, Paul
AU  - Zomer P
FAU - Mol, Hans
AU  - Mol H
FAU - Hajslova, Jana
AU  - Hajslova J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110712
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Thiocarbamates)
SB  - IM
MH  - Fruit/*chemistry
MH  - Fungicides, Industrial/*analysis
MH  - Mass Spectrometry/*methods
MH  - Thiocarbamates/*analysis
EDAT- 2011/07/14 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1080/19440049.2011.590456 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 
      Oct;28(10):1372-82. doi: 10.1080/19440049.2011.590456. Epub 2011 Jul 12.