PMID- 21751159
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20220317
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 10
IP  - 3
DP  - 2011 Jul 5
TI  - Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese 
      patients.
PG  - 1331-6
LID - 10.4238/vol10-3gmr1132 [doi]
AB  - Human leukocyte antigen (HLA) plays a central role in the regulation of the 
      immune response. HLA class II molecules are essential for T cell-mediated 
      adaptive immunity and present peptide antigens to CD4(+) T cells. Because of its 
      important role in the immune response and its high degree of polymorphism, the 
      HLA system is associated with many diseases. We examined the polymorphisms of 
      HLA-DRB alleles and the sequences of the HLA-DRB promoter region in 97 unrelated 
      patients with pulmonary tuberculosis and in 62 unrelated normal controls of the 
      Han nationality from North China, using PCR with sequence-specific primers and 
      PCR direct sequencing. We found that the frequency of HLA-DRB1*15 was 
      significantly higher in the pulmonary tuberculosis group than in the healthy 
      control group. The P value was 0.001, and the odds ratio was 3.793. The pulmonary 
      tuberculosis group had the same HLA-DRB1 promoter region sequences as the control 
      group. We concluded that the HLA-DRB1*15 allele is associated with pulmonary 
      tuberculosis in the Han nationality from North China. The HLA-DRB1 promoter 
      region sequences had no association with the development of pulmonary 
      tuberculosis.
FAU - Shi, G L
AU  - Shi GL
AD  - Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic 
      Tumor Research Institute, P.R. China. shiguangli878@sina.com
FAU - Hu, X L
AU  - Hu XL
FAU - Yang, L
AU  - Yang L
FAU - Rong, C L
AU  - Rong CL
FAU - Guo, Y L
AU  - Guo YL
FAU - Song, C X
AU  - Song CX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Tuberculosis, Pulmonary/*genetics
MH  - Young Adult
EDAT- 2011/07/14 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - gmr1132 [pii]
AID - 10.4238/vol10-3gmr1132 [doi]
PST - epublish
SO  - Genet Mol Res. 2011 Jul 5;10(3):1331-6. doi: 10.4238/vol10-3gmr1132.