PMID- 21751547
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110714
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 30
IP  - 180
DP  - 2011 Jun
TI  - [Intravenously applied immunoglobulin in systemic, autoimmune and vasculitis 
      diseases in children].
PG  - 400-4
AB  - Intravenous immunoglobulin (IVIG) have been widely used in clinical practice for 
      more than 35 years. Their specificity and diversity and their relative safety 
      make them potent therapy in antibody deficiencies, certain infections and several 
      autoimmune and inflammatory disorders. IVIG is a biological drug that is used 
      routinely for idiopathic thrombocytopenic purpura, Kawasaki disease, and 
      Guillain-Barre syndrome. Therapeutic approaches for autoimmune diseases are 
      primarily based on suppressive measures that down regulate an over productive 
      immune system. IVIG efficacy has been established in many clinical trials for 
      various autoimmune diseases, vasculitis and neuroimmunological, dermatological 
      and hematological disorders. Despite the evidence of efficacy, there are no 
      generally accepted therapeutic guidelines, the dosage and timing of IVIG therapy, 
      and questions of costs/benefits ratio still remain insufficiently documented and 
      multicentric controlled clinical trials are necessary. Most available evidence 
      for a benefit for IVIG in children comes from uncontrolled open series or case 
      reports.
FAU - Zeman, Krzysztof
AU  - Zeman K
AD  - Uniwersytet Medyczny w Lodzi, Klinika Pediatrii Kardiologii Prewencyjnej i 
      Immunologii Wieku Rozwojowego. krzysztof.zeman@umed.lodz.pl
FAU - Cywinska-Bernas, Agnieszka
AU  - Cywinska-Bernas A
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Preparaty immunoglobulin w leczeniu chorob ukladowych o podlozu 
      autoimmunizacyjnym i zapaleniach naczyn u dzieci.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Autoimmune Diseases/*drug therapy
MH  - Child
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Vasculitis/*drug therapy
EDAT- 2011/07/15 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Pol Merkur Lekarski. 2011 Jun;30(180):400-4.