PMID- 21751555
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20191210
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 30
IP  - 180
DP  - 2011 Jun
TI  - [The role of intravenous immunoglobulin in the treatment of rheumatic diseases in 
      adults].
PG  - 435-40
AB  - Intravenous immunoglobulin (IVIG) preparations have been used as substitutional 
      treatment in hypogammaglobulinemia for a long time. IVIG has now become an 
      important treatment option in a number of clinical indications including 
      autoimmune and acute inflammatory conditions. The mechanism of action is complex 
      and not fully understood. The role of IVIG in many rheumatic diseases remain 
      unclear and controversial because there are no randomized studies to support the 
      use of IVIG. In 2006 the Department of Health in the UK started a process to 
      review the use of immunoglobulin in various clinical indications and in 2008 the 
      clinical guidelines for immunoglobulin use were published. Despite the 
      introduction of newer biologic treatments IVIG could be a good treatment options 
      in same patients with rheumatic diseases. Frequently they are used as second-line 
      drugs after failure of therapy with corticosteroids and immunosuppressive drugs. 
      As a first-line drugs in addition to Kawasaki disease the use of IVIG can be 
      considered in the treatment of systemic connective tissue diseases when there are 
      contraindications to the use of corticosteroids or immunosuppressive drugs, there 
      are associated infections (including tuberculosis) and in pregnant women.
FAU - Swierkot, Jerzy
AU  - Swierkot J
AD  - Akademia Medyczna we Wroclawiu, Katedra i Klinika Reumatologii i Chorob 
      Wewnetrznych. jurekswierkot0@poczta.onet.pl
FAU - Lewandowicz-Uszynska, Aleksandra
AU  - Lewandowicz-Uszynska A
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Rola immunoglobulin dozylnych (IVIG) w leczeniu chorob reumatologicznych u 
      doroslych.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/drug therapy
MH  - Contraindications
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Infections/chemically induced
MH  - Pregnancy
MH  - Pregnancy Complications/chemically induced/drug therapy
MH  - Rheumatic Diseases/*drug therapy
EDAT- 2011/07/15 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Pol Merkur Lekarski. 2011 Jun;30(180):435-40.