PMID- 21752743
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20221207
IS  - 1878-0210 (Electronic)
IS  - 1878-0210 (Linking)
VI  - 5
IP  - 4
DP  - 2011 Dec
TI  - PANORAMA: a European study to evaluate quality of life and treatment satisfaction 
      in patients with type-2 diabetes mellitus--study design.
PG  - 231-9
LID - 10.1016/j.pcd.2011.04.004 [doi]
AB  - AIM: Type-2 diabetes mellitus (T2DM) is a major cause of disability reaching 
      epidemic proportions worldwide. The disease burden of T2DM is commonly 
      characterised using health status measures, but few European-wide data are 
      available concerning patients' views of their quality of life (QoL) and other 
      patient-reported outcomes (PROs). Despite evidence supporting benefits of 
      glycaemic control, many patients are currently not treated to recommended HbA(1c) 
      targets (<7%). Consequently, the prevalence of T2DM-related chronic complications 
      remains high, impacting negatively on patients' health status. Hypoglycaemia is a 
      side effect associated with some antidiabetes medications that may also diminish 
      QoL and treatment satisfaction. The aim of the PANORAMA study (NCT00916513) is to 
      evaluate QoL and other PROs in patients with T2DM. It will investigate the 
      association between these variables, the different diabetes treatment regimens 
      used and levels of glycaemic control achieved across Europe. This report 
      describes the rationale for conducting the PANORAMA study, and the study design. 
      METHODS: PANORAMA is an observational, multicentre, multinational, 
      cross-sectional study. Approximately 5000 patients with T2DM currently treated 
      with diet, oral antidiabetes agents and/or injectables (insulin and/or 
      glucagon-like peptide-1 [GLP-1] analogues), >/=1-year follow up, will be randomly 
      selected from a representative sample of mainly primary care practices across 
      nine countries. Patient demographics; HbA(1c) level (standardised measurement); 
      PROs, including QoL (ADDQoL), health status (EQ-5D), treatment satisfaction 
      (DTSQ) and fear of hypoglycaemia (HFS-II); disease-related variables; 
      health-economic variables; physician demographics and physician-reported outcomes 
      will be collected. DISCUSSION: The large-scale, European-wide PANORAMA study is 
      designed to evaluate QoL and other PROs in patients with T2DM.
CI  - Copyright (c) 2011 Clare Bradley. Published by Elsevier Ltd.. All rights reserved.
FAU - Bradley, Clare
AU  - Bradley C
AD  - Department of Psychology, Royal Holloway, University of London, Egham, Surrey, 
      UK. c.bradley@rhul.ac.uk
FAU - de Pablos-Velasco, Pedro
AU  - de Pablos-Velasco P
FAU - Parhofer, Klaus G
AU  - Parhofer KG
FAU - Eschwege, Eveline
AU  - Eschwege E
FAU - Gonder-Frederick, Linda
AU  - Gonder-Frederick L
FAU - Simon, Dominique
AU  - Simon D
LA  - eng
SI  - ClinicalTrials.gov/NCT00916513
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110714
PL  - England
TA  - Prim Care Diabetes
JT  - Primary care diabetes
JID - 101463825
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/drug effects/metabolism
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*drug therapy/*psychology
MH  - Europe
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemia/chemically induced
MH  - Hypoglycemic Agents/adverse effects/*therapeutic use
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - *Patient Satisfaction
MH  - *Quality of Life
MH  - *Research Design
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2011/07/15 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/07/15 06:00
PHST- 2010/11/18 00:00 [received]
PHST- 2011/04/20 00:00 [revised]
PHST- 2011/04/26 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S1751-9918(11)00030-1 [pii]
AID - 10.1016/j.pcd.2011.04.004 [doi]
PST - ppublish
SO  - Prim Care Diabetes. 2011 Dec;5(4):231-9. doi: 10.1016/j.pcd.2011.04.004. Epub 
      2011 Jul 14.