PMID- 21754925
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Print)
IS  - 1687-6121 (Linking)
VI  - 2011
DP  - 2011
TI  - Connexin43 Expression Increases in the Epithelium and Stroma along the Colonic 
      Neoplastic Progression Pathway: Implications for Its Oncogenic Role.
PG  - 561719
LID - 10.1155/2011/561719 [doi]
LID - 561719
AB  - Connexins (Cxs) are critical for normal tissue development, differentiation, and 
      cell proliferation. Normal expression and function of Cxs are considered to play 
      a role in tumor suppression, but abnormal localization and abnormally increased 
      expression of Cxs have been found in a variety of carcinomas. Of the Cx family, 
      Cx43 is a most prevalent member and has been known as a downstream target of 
      beta-catenin, a key component of Wnt signaling pathway. We evaluated the expression 
      of Cx43 in the colonic neoplasia progression sequence with additional attention 
      to the stromal component. Resections of 50 colonic adenocarcinomas were stained 
      immunohistochemically for Cx43 on paraffin embedded sections. Cx43 cytoplasmic 
      expression increased progressively in the colonic adenocarcinoma sequence in both 
      the epithelial [normal (4 +/- 1), adenomatous (20 +/- 2), cancerous (124 +/- 10) (P < 
      0.01)], and stromal [normal (19 +/- 1), cancerous (45 +/- 4) (P < 0.01)] components. 
      In the epithelial component, Cx43 was expressed lower in stage I adenocarcinomas 
      (69 +/- 12) compared to stage III/IV (158 +/- 10, P < 0.01). Additionally, Cx43 was 
      relatively increased in the adenocarcinoma at the invasive tumor front in all 
      stages. Cx43 may play a critical role in the pathogenesis of colon cancer via gap 
      junction or other gap junction independent mechanisms such as the Wnt/beta-catenin 
      pathway.
FAU - Han, Yusheng
AU  - Han Y
AD  - Department of Pathology and Laboratory Medicine, Pennsylvania Hospital, 
      Philadelphia, PA 19107, USA.
FAU - Zhang, Paul J
AU  - Zhang PJ
FAU - Chen, Terina
AU  - Chen T
FAU - Yum, Sabrina W
AU  - Yum SW
FAU - Pasha, Teresa
AU  - Pasha T
FAU - Furth, Emma E
AU  - Furth EE
LA  - eng
PT  - Journal Article
DEP - 20110630
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC3132986
EDAT- 2011/07/15 06:00
MHDA- 2011/07/15 06:01
PMCR- 2011/06/30
CRDT- 2011/07/15 06:00
PHST- 2011/02/22 00:00 [received]
PHST- 2011/04/28 00:00 [revised]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/07/15 06:01 [medline]
PHST- 2011/06/30 00:00 [pmc-release]
AID - 10.1155/2011/561719 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2011;2011:561719. doi: 10.1155/2011/561719. Epub 2011 
      Jun 30.