PMID- 21755025
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 2042-0099 (Electronic)
IS  - 2042-0099 (Linking)
VI  - 2011
DP  - 2011
TI  - Definition of nonresponse to analgesic treatment of arthritic pain: an analytical 
      literature review of the smallest detectable difference, the minimal detectable 
      change, and the minimal clinically important difference on the pain visual analog 
      scale.
PG  - 231926
LID - 10.4061/2011/231926 [doi]
LID - 231926
AB  - Our objective was to develop a working definition of nonresponse to analgesic 
      treatment of arthritis, focusing on the measurement of pain on the 0-100 mm pain 
      visual analog scale (VAS). We reviewed the literature to assess the smallest 
      detectable difference (SDD), the minimal detectable change (MDC), and the minimal 
      clinically important difference (MCID). The SDD for improvement reported in three 
      studies of rheumatoid arthritis was 18.6, 19.0, and 20.0. The median MDC was 25.4 
      for 7 studies of osteoarthritis and 5 studies of rheumatoid arthritis (calculated 
      for a reliability coefficient of 0.85). The MCID increased with increasing 
      baseline pain score. For baseline VAS tertiles defined by scores of 30-49, 50-65, 
      and >65, the MCID for improvement was, respectively, 7-11 units, 19-27 units, and 
      29-37 units. Nonresponse can thus be defined in terms of the MDC for low baseline 
      pain scores and in terms of the MCID for high baseline scores.
FAU - Stauffer, Melissa E
AU  - Stauffer ME
AD  - Scribco Pharmaceutical Writing, P.O. Box 1525, Blue Bell, PA 19422, USA.
FAU - Taylor, Stephanie D
AU  - Taylor SD
FAU - Watson, Douglas J
AU  - Watson DJ
FAU - Peloso, Paul M
AU  - Peloso PM
FAU - Morrison, Alan
AU  - Morrison A
LA  - eng
PT  - Journal Article
DEP - 20110505
PL  - United States
TA  - Int J Inflam
JT  - International journal of inflammation
JID - 101538188
PMC - PMC3132608
EDAT- 2011/07/15 06:00
MHDA- 2011/07/15 06:01
PMCR- 2011/05/05
CRDT- 2011/07/15 06:00
PHST- 2011/01/25 00:00 [received]
PHST- 2011/03/08 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/07/15 06:01 [medline]
PHST- 2011/05/05 00:00 [pmc-release]
AID - 10.4061/2011/231926 [doi]
PST - ppublish
SO  - Int J Inflam. 2011;2011:231926. doi: 10.4061/2011/231926. Epub 2011 May 5.