PMID- 21755501
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20110812
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 83
IP  - 10
DP  - 2011 Oct
TI  - Killer cell immunoglobulin-like receptors and response to antiviral treatment in 
      Thai patients with chronic hepatitis C virus genotype 3a.
PG  - 1733-7
LID - 10.1002/jmv.22153 [doi]
AB  - Genetic factors of the host have been shown to influence the outcome of treatment 
      for hepatitis C virus (HCV) infection. Killer cell immunoglobulin-like receptors 
      (KIR) regulate natural killer (NK) cell activity by interaction with specific 
      human leukocyte antigen (HLA) class I. In this study, KIR gene polymorphisms and 
      their HLA ligands were investigated in 110 Thai patients with chronic HCV 
      genotype 3a. Seventy-six patients were sustained virological responders and 34 
      patients were virological non-responders. KIR typing and HLA-C typing were 
      performed using PCR-SSP (polymerase chain reaction with sequence specific 
      primer). The frequency of HLA-C1C2 was significantly higher in sustained 
      responders than in non-responders (P = 0.04). However, the frequencies of 
      KIR2DL2/2DL3 genotype and KIR2DL2/2DL3-HLA-C1C1 genotype were significantly 
      higher in non-responders than in sustained responders (P = 0.02, 0.004, 
      respectively). In summary, this study showed the association of KIR genes and 
      ligands with the outcome of antiviral treatment in chronic hepatic C virus 
      genotype 3a infection.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Vejbaesya, Sasijit
AU  - Vejbaesya S
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Mahidol University, Bangkok, Thailand. sisve@mahidol.ac.th
FAU - Nonnoi, Yuwatida
AU  - Nonnoi Y
FAU - Tanwandee, Tawesak
AU  - Tanwandee T
FAU - Srinak, Duangporn
AU  - Srinak D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiviral Agents/immunology/*therapeutic use
MH  - Female
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-C Antigens/*genetics/immunology
MH  - Hepacivirus/genetics/immunology
MH  - Hepatitis C, Chronic/*drug therapy/*immunology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Ligands
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, KIR/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Thailand
MH  - Treatment Outcome
EDAT- 2011/07/15 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1002/jmv.22153 [doi]
PST - ppublish
SO  - J Med Virol. 2011 Oct;83(10):1733-7. doi: 10.1002/jmv.22153. Epub 2011 Jul 13.