PMID- 21757965
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20120131
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 47
IP  - 2
DP  - 2012
TI  - Drusen characteristics revealed by spectral-domain optical coherence tomography 
      and their corresponding fundus autofluorescence appearance in dry age-related 
      macular degeneration.
PG  - 81-6
LID - 10.1159/000324988 [doi]
AB  - PURPOSE: To analyze the relationship between drusen morphology revealed by 
      spectral-domain optical coherence tomography (SD-OCT) and corresponding fundus 
      autofluorescence (FAF) features of the same drusen using the Heidelberg Retina 
      Angiograph 2 (HRA2), in patients with dry age-related macular degeneration (AMD). 
      METHODS: Dry AMD patients were imaged with SD-OCT and HRA2 on the same day. 
      SD-OCT B scans were then precisely overlaid onto the HRA2 images, and the SD-OCT 
      morphological characteristics of the drusen were correlated with the 
      corresponding FAF appearance. The analyzed morphological features of the drusen 
      included: size, status of the inner segment/outer segment (IS-OS) junctional 
      layer above the drusen, shape of the drusen, internal reflectivity, homogeneity 
      and presence of overlaying hyperreflective foci. The FAF characteristics of each 
      druse were rated as hyperautofluorescent, hypoautofluorescent or normally 
      autofluorescent. Spearman's correlation coefficient was used to analyze the 
      correlation between the 2 primary outcomes: SD-OCT morphology of the drusen and 
      their autofluorescent appearance. RESULTS: 431 drusen in 32 eyes of 16 dry AMD 
      patients were evaluated. Of the 7 morphological characteristics assessed by 
      SD-OCT, only drusen size and the status of the IS-OS layer above the drusen were 
      strongly correlated with the autofluorescent appearance (r = 0.78, p < 0.001, and 
      r = 0.58, p < 0.001, respectively). The strength of correlation with other 
      features appeared less robust: homogeneity (r = 0.38; p = 0.001), shape (r = 
      0.29; p = 0.004), reflectivity (r = 0.28; p = 0.004) and presence of overlaying 
      foci (r = 0.25; p = 0.12). CONCLUSIONS: Autofluorescent changes most strongly 
      correlate with drusen size and disruption of the IS-OS layer and may be useful as 
      an additional functional-morphological feature by which drusen and their impact 
      upon overlying photoreceptors may be judged.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Landa, Gennady
AU  - Landa G
AD  - Retina Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New 
      York, N.Y., USA.
FAU - Rosen, Richard B
AU  - Rosen RB
FAU - Pilavas, John
AU  - Pilavas J
FAU - Garcia, Patricia M T
AU  - Garcia PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Macular Degeneration/*diagnosis/pathology
MH  - Male
MH  - Retinal Drusen/*diagnosis/pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2011/07/16 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/07/16 06:00
PHST- 2010/10/20 00:00 [received]
PHST- 2011/02/09 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 000324988 [pii]
AID - 10.1159/000324988 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2012;47(2):81-6. doi: 10.1159/000324988. Epub 2011 Jul 13.