PMID- 21761711
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20131121
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Apr
TI  - [Clinical observation of Clarithromycin combined with nasal steroid treatment for 
      chronic rhinosinusitis].
PG  - 360-3
AB  - OBJECTIVE: To observe the clinical treatment effectiveness of Clarithromycin 
      combined with nasal glucocorticoids for chronic rhinosinusitis (CRS). METHOD: 
      Clarithromycin was 0.25 g a day (the first two weeks was 0.25 g twice a day) and 
      topical Triamcinolone Acetonide Acetate nasal spray was (220 microg/d) once a 
      day. Fifty-six patients were enrolled in our research. Twenty-six patients of CRS 
      without nasal polyps was treated for 12 to 28 weeks (average 16.62 weeks). Thirty 
      patients of CRS with nasal polyps was treated for 12 to 33 weeks (average 20.03 
      weeks) after polypectomy. The patients' symptom were evaluated through Sino-Nasal 
      Outcome Test 20 (SNOT-20) scale. Meanwhile sinus CT were evaluated by Lund-Mackey 
      system before and after operation. RESULT: The score of CT scan was significantly 
      decreased to 2.83 +/- 1.86 (t = 11.41, P < 0.01) in the CRS with nasal polyps 
      group and to 2.43 +/- 1.91 (t = 12.86, P < 0.01) in the CRS without nasal polyps 
      group after treatment. Recovery rate of CRS with nasal polyps group was 43.3% and 
      of CRS without nasal polyps group was 50.0% with CT images. The self assessments 
      of treatment efficiency was coincident with CT image in the two groups. 
      CONCLUSION: The treatment with Long term use of low dosage oral macrolide 
      Clarithromycin combined with nasal steroid on CRS was efficacy. Polypectomy 
      ,large dose antibiotic and steroid used in intraoperative period could 
      significant improve the treatment efficiency of CRS with nasal polyps.
FAU - Liu, Jubo
AU  - Liu J
AD  - Department of Otorhinolaryngology, the Disabled Soldiers, Hospital of Guangdong 
      Province, Guangzhou, 510260, China. entliu0503@163.com
FAU - Liu, Liya
AU  - Liu L
FAU - Lu, Xiang
AU  - Lu X
FAU - Zhong, Gangyi
AU  - Zhong G
FAU - Wan, Ying
AU  - Wan Y
FAU - Li, Qiang
AU  - Li Q
FAU - Feng, Zhijian
AU  - Feng Z
FAU - Li, Xianhua
AU  - Li X
FAU - Hong, Yichun
AU  - Hong Y
LA  - chi
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Clarithromycin/*administration & dosage/therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/drug therapy
MH  - Rhinitis/*drug therapy
MH  - Sinusitis/*drug therapy
MH  - Treatment Outcome
MH  - Triamcinolone Acetonide/*administration & dosage/therapeutic use
MH  - Young Adult
EDAT- 2011/07/19 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Apr;25(8):360-3.