PMID- 21761841
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20131121
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 59
IP  - 16
DP  - 2011 Aug 24
TI  - Antioxidative caffeoylquinic acids and flavonoids from Hemerocallis fulva 
      flowers.
PG  - 8789-95
LID - 10.1021/jf201166b [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species (ROS) production 
      in HepG2 was used to screen hepatocyte protective compounds from the flowers of 
      Hemerocallis fulva. Three new polyphenols, n-butyl 4-trans-O-caffeoylquinate (1), 
      kaempferol 
      3-O-alpha-L-rhamnopyranosyl(1-->6)[alpha-L-rhamnopyranosyl(1-->2)]-beta-D-galactopyranoside 
      (2), and chrysoeriol 
      7-O-[beta-D-glucuronopyranosyl(1-->2)(2-O-trans-feruloyl)-beta-D-glucuronopyranoside (3), 
      together with four caffeoylquinic acid derivatives (4-7), eight known flavones 
      (8-15), one naphthalene glycoside, stelladerol (16), one tryptophan derivative 
      (17), adenosine (18), and guanosine (19) were isolated from the bioactive 
      fractions of the aqueous ethanol extract of H. fulva flowers. The structures of 
      isolated compounds were characterized by means of spectroscopic data. Compounds 
      1-3 were described as first isolated natural products. Among the above-mentioned 
      compounds, the caffeoylquinic acid derivatives are the major components with 
      potent free radical scavenging activity in HepG2 cells and are for the first time 
      isolated from H. fulva flowers. A convenient ultraperformance liquid 
      chromatography (UPLC) method was also developed to simultaneously separate and 
      identify caffeoylquinic acids and flavonoids promptly.
FAU - Lin, Yun-Lian
AU  - Lin YL
AD  - National Research Institute of Chinese Medicine, Taipei, Taiwan. 
      yllin@nricm.edu.tw
FAU - Lu, Chung-Kuang
AU  - Lu CK
FAU - Huang, Yeh-Jeng
AU  - Huang YJ
FAU - Chen, Hong-Jhang
AU  - Chen HJ
LA  - eng
PT  - Journal Article
DEP - 20110722
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Polyphenols)
RN  - 0 (caffeoylquinic acid)
RN  - 058C04BGYI (Quinic Acid)
SB  - IM
MH  - *Antioxidants/isolation & purification/pharmacology
MH  - Chromatography, High Pressure Liquid/methods
MH  - Flavonoids/chemistry/*isolation & purification/pharmacology
MH  - Flowers/*chemistry
MH  - Free Radical Scavengers
MH  - Hemerocallis/*chemistry
MH  - Hep G2 Cells
MH  - Humans
MH  - Polyphenols/chemistry/isolation & purification/pharmacology
MH  - Quinic Acid/*analogs & derivatives/isolation & purification/pharmacology
EDAT- 2011/07/19 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1021/jf201166b [doi]
PST - ppublish
SO  - J Agric Food Chem. 2011 Aug 24;59(16):8789-95. doi: 10.1021/jf201166b. Epub 2011 
      Jul 22.