PMID- 21762744
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 10
DP  - 2011 Oct
TI  - The distribution of human leukocyte antigen-A, -B, and -DRB1 alleles and 
      haplotypes based on high-resolution genotyping of 167 families from Jiangsu 
      Province, China.
PG  - 872-6
LID - 10.1016/j.humimm.2011.06.006 [doi]
AB  - We investigated the human leukocyte antigen (HLA)-A, -B, and -DRB1 allele 
      frequencies, the A-B-DRB1, A-B, B-DRB1, and A-DRB1 haplotype frequencies, and the 
      characteristics of linkage disequilibrium between 2 loci in high resolution based 
      on 167 unrelated families from Jiangsu Province, China. A total of 26 alleles at 
      the A locus, 55 alleles at the B locus, and 34 alleles at the DRB1 locus were 
      reported in this study. The top 5 most frequent HLA alleles at the HLA-A, -B, and 
      -DRB1 loci, respectively, were A*11:01, A*24:02, A*02:01, A*33:03, A*30:01; 
      B*13:02, B*40:01 B*46:01, B*58:01, B*54:01; DRB1*09:01, DRB1*07:01, DRB1*12:02, 
      DRB1*15:01, and DRB1*08:03. Several haplotypes with high frequencies were deduced 
      in this study. The top 3 most common A-B-DRB1 haplotypes observed were 
      A*30:01-B*13:02-DRB1*07:01, A*33:03-B*58:01-DRB1*03:01, and 
      A*02:07-B*46:01-DRB1*09:01. The top 3 most common A-B haplotypes were 
      A*30:01-B*13:02, A*33:03-B*58:01, and A*02:07-B*46:01. The top 4 most common 
      A-DRB1 haplotypes were A*30:01-DRB1*07:01, A*33:03-DRB1*13:02, 
      A*24:02-DRB1*09:01, and A*33:03-DRB1*03:01. Finally, the top 3 most common B-DRB1 
      haplotypes were B*13:02-DRB1*07:01, B*46:01-DRB1*09:01, and B*58:01-DRB1*03:01. 
      From the linkage disequilibrium calculation, the most prominent associations were 
      A*30:01-B*13:02, B*13:02-DRB1*07:01, and A*01:03-DRB1*01:02. These allele and 
      haplotype frequencies could be useful for finding the best matched donors for 
      patients in the China Marrow Donor Program Jiangsu Branch.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Pan, Qin-Qin
AU  - Pan QQ
AD  - HLA Laboratory, First Affiliated Hospital with Nanjing Medical University, 
      Nanjing, China.
FAU - Fan, Su
AU  - Fan S
FAU - Wang, Xiao-Yan
AU  - Wang XY
FAU - Pan, Meng
AU  - Pan M
FAU - Zhao, Xing
AU  - Zhao X
FAU - Zhou, Xiao-Yu
AU  - Zhou XY
FAU - Wang, Cheng-Ya
AU  - Wang CY
FAU - Shen, Jie
AU  - Shen J
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Loci
MH  - *Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*analysis/genetics/immunology
MH  - HLA-B Antigens/*analysis/genetics/immunology
MH  - HLA-DRB1 Chains/*analysis/genetics/immunology
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Leukocytes/*chemistry/cytology/immunology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Phylogeny
EDAT- 2011/07/19 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/05/27 00:00 [revised]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - S0198-8859(11)00152-2 [pii]
AID - 10.1016/j.humimm.2011.06.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Oct;72(10):872-6. doi: 10.1016/j.humimm.2011.06.006. Epub 2011 
      Jul 1.