PMID- 21762745
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 10
DP  - 2011 Oct
TI  - Susceptibility to aplastic anemia is associated with HLA-DRB1*1501 in an 
      aboriginal population in Sabah, Malaysia.
PG  - 889-92
LID - 10.1016/j.humimm.2011.06.013 [doi]
AB  - The incidence of aplastic anemia is reported to be higher in Asia than elsewhere. 
      We studied the frequency of human leukocyte antigen (HLA) DRB1 alleles in 
      aplastic anemia patients from 2 genetically similar aboriginal groups, the 
      Kadazan and the Dusun, and compared them with genetically matched community and 
      hospital controls. HLA-DRB1*15 was significantly higher in the patients compared 
      with controls (p = 0.005), confirming similar findings in Japanese and Caucasian 
      studies. Further testing indicated a significantly higher frequency of 
      HLA-DRB1*1501 in patients compared with controls (p = 0.0004) but no significant 
      difference in the frequency of HLA-DRB1*1502. The high frequency of HLA-DRB1*15 
      in the Kadazan and Dusun population combined with the wide variety of 
      environmental factors associated with aplastic anemia could be the reason for the 
      elevated incidence of aplastic anemia in the Kadazan and Dusun in Sabah.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Dhaliwal, J S
AU  - Dhaliwal JS
AD  - Allergy and Immunology Research Centre, Institute for Medical Research, Jalan 
      Pahang, Kuala Lumpur, Malaysia. jasbir@imr.gov.my
FAU - Wong, Lily
AU  - Wong L
FAU - Kamaluddin, Muhammad Amir
AU  - Kamaluddin MA
FAU - Yin, Lee Yin
AU  - Yin LY
FAU - Murad, Shahnaz
AU  - Murad S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110701
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Anemia, Aplastic/ethnology/*genetics/immunology/physiopathology
MH  - *Asian People
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DRB1 Chains/*analysis/genetics/immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Incidence
MH  - Leukocytes/chemistry/cytology/*immunology
MH  - Malaysia/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
EDAT- 2011/07/19 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/07/19 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/06/12 00:00 [revised]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - S0198-8859(11)00159-5 [pii]
AID - 10.1016/j.humimm.2011.06.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Oct;72(10):889-92. doi: 10.1016/j.humimm.2011.06.013. Epub 2011 
      Jul 1.