PMID- 21762746
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20220321
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 10
DP  - 2011 Oct
TI  - Association of MICA and MICB alleles with symptomatic dengue infection.
PG  - 904-7
LID - 10.1016/j.humimm.2011.06.010 [doi]
AB  - Dengue viruses (DV) are one of the most important arthropod-borne viral diseases 
      in the developing world. DV can cause syndromes that are either self-limiting or 
      severe. Allelic variants of human leukocyte antigen (HLA) genes have been 
      demonstrated to be associated with disease susceptibility. Here we report the 
      association of nonclassical HLA class I MICA-MICB genes with disease outcome 
      during DV infection. A sequencing-based typing method and genotyping of MICA and 
      MICB in a well-characterized group of Cuban individuals with dengue hemorrhagic 
      fever (DHF), dengue fever (DF), or asymptomatic dengue infection (ADI) was 
      performed. Statistical analysis revealed a tendency for MICA*008 and MICB*008 to 
      associate with susceptibility to illness when symptomatic versus asymptomatic 
      cases (odds ratio [OR] = 2.1, p(v) = 0.03, and OR = 10.4, p = 0.0096, 
      respectively) were compared. Surprisingly, a stronger association of both allelic 
      forms was observed for the DF patients compared with the ADI group (MICA*008, OR 
      = 5.2, p = 0.0001; and MICB*008, OR = 13.2, p = 0.0025) rather than the severe 
      cases. Major histocompatibility class I-related gene-related natural killer cells 
      and/or gammadelta and alphabeta T-cell activation might regulate the development of symptomatic 
      DF and DHF.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Garcia, Gissel
AU  - Garcia G
AD  - Department of Virology, Tropical Medicine Institute Pedro Kouri, Habana, Cuba.
FAU - del Puerto, Florencia
AU  - del Puerto F
FAU - Perez, Ana B
AU  - Perez AB
FAU - Sierra, Beatriz
AU  - Sierra B
FAU - Aguirre, Eglys
AU  - Aguirre E
FAU - Kikuchi, Mihoko
AU  - Kikuchi M
FAU - Sanchez, Lizet
AU  - Sanchez L
FAU - Hirayama, Kenji
AU  - Hirayama K
FAU - Guzman, Maria G
AU  - Guzman MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110701
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (MICB antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asymptomatic Infections
MH  - Cuba/epidemiology
MH  - Dengue Virus/*immunology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Molecular Typing
MH  - Polymorphism, Genetic
MH  - Severe Dengue/epidemiology/*genetics/immunology/virology
MH  - Severity of Illness Index
MH  - T-Lymphocytes/immunology
EDAT- 2011/07/19 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/06/16 00:00 [revised]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - S0198-8859(11)00156-X [pii]
AID - 10.1016/j.humimm.2011.06.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Oct;72(10):904-7. doi: 10.1016/j.humimm.2011.06.010. Epub 2011 
      Jul 1.