PMID- 21762765
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20201209
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 137
IP  - 1
DP  - 2011 Sep 1
TI  - Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic 
      dermatitis by the water extract of Lindera obtusiloba.
PG  - 802-7
LID - 10.1016/j.jep.2011.06.043 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: The Lindera obtusiloba has been used in 
      traditional medicine for the treatment of inflammation and dermatitis. In this 
      study, we investigated the effect of topical application of Lindera obtusiloba 
      water extract (LOWE) on the house dust mite extract (Dermatophagoides farinae 
      extract, DFE) and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). 
      MATERIALS AND METHODS: We established AD model in BALB/c mice by repeated local 
      exposure of DFE/DNCB to the ears. After a topical application of LOWE on the skin 
      lesions, the epidermal thickness, mast cell infiltration, and serum 
      immunoglobulin E (IgE) and histamine were measured. In addition, the gene 
      expression of interleukin (IL)-4, IL-13, IL-31, and tumor necrosis factor (TNF)-alpha 
      in the ears was assayed. RESULTS: LOWE reduced AD symptoms based on ear 
      thickness, histopathological analysis, and serum IgE levels. LOWE inhibited mast 
      cell infiltration into the ear and elevation of serum histamine in AD model. 
      Moreover, LOWE suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-31, and 
      TNF-alpha in the ears. CONCLUSIONS: Our results showed that topical application of 
      LOWE exerts beneficial effects in AD symptoms, suggesting that LOWE might be a 
      candidate for the treatment of AD.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Choi, Eun-Ju
AU  - Choi EJ
AD  - Division of Sport Science, College of Natural Sciences, Konkuk University, 
      Chungbuk 380-702, Republic of Korea.
FAU - Lee, Soyoung
AU  - Lee S
FAU - Kim, Hui-Hun
AU  - Kim HH
FAU - Singh, Thoudam S K
AU  - Singh TS
FAU - Choi, Jin Kyeong
AU  - Choi JK
FAU - Choi, Hyun Gyu
AU  - Choi HG
FAU - Suh, Won Mo
AU  - Suh WM
FAU - Lee, Seung-Ho
AU  - Lee SH
FAU - Kim, Sang-Hyun
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin-31, mouse)
RN  - 059QF0KO0R (Water)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Anti-Allergic Agents/administration & dosage/chemistry/isolation & 
      purification/*pharmacology
MH  - Antigens, Dermatophagoides
MH  - Dermatitis, Atopic/chemically induced/genetics/immunology/pathology/*prevention & 
      control
MH  - Dinitrochlorobenzene
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Ear
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Histamine/blood
MH  - Immunoglobulin E/blood
MH  - Interleukin-13/genetics
MH  - Interleukin-4/genetics
MH  - Interleukins/genetics
MH  - *Lindera/chemistry
MH  - Mast Cells/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/administration & dosage/chemistry/isolation & 
      purification/*pharmacology
MH  - Plants, Medicinal
MH  - Skin/*drug effects/immunology/pathology
MH  - Solvents/*chemistry
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Water/*chemistry
EDAT- 2011/07/19 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/06/17 00:00 [revised]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0378-8741(11)00472-7 [pii]
AID - 10.1016/j.jep.2011.06.043 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Sep 1;137(1):802-7. doi: 10.1016/j.jep.2011.06.043. Epub 
      2011 Jul 5.