PMID- 21764829
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20221207
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Linking)
VI  - 20
IP  - 19
DP  - 2011 Oct 1
TI  - A genome-wide association study of hepatitis B vaccine response in an Indonesian 
      population reveals multiple independent risk variants in the HLA region.
PG  - 3893-8
LID - 10.1093/hmg/ddr302 [doi]
AB  - We performed a two-stage genome-wide association study (GWAS) of antibody titer 
      in 3614 hepatitis B vaccine recipients from Indonesia's Riau Archipelago, leading 
      to the identification of at least three independent signals within the human 
      leukocyte antigen (HLA) complex. These appear to implicate HLA-DR [rs3135363; P= 
      6.53 x 10(-22); odds ratio (OR) = 1.53, 95% confidence interval (CI) = 
      1.35-1.74]; HLA-DP, previously associated with the risk of chronic hepatitis B 
      infection (rs9277535; P= 2.91 x 10(-12); OR = 0.72, 95% CI = 0.63-0.81); and a 
      gene rich HLA Class III interval (rs9267665; P = 1.24 x 10(-17); OR = 2.05, CI = 
      1.64-2.57). The substantial overlap of these variants and those identified by 
      GWAS of chronic hepatitis B infection confirms vaccine response as a model for 
      infection, while suggesting that the vaccine is least effective in those most at 
      risk of lifelong infection, following exposure to the virus.
FAU - Png, Eileen
AU  - Png E
AD  - 1Human Genetics, Genome Institute of Singapore, Singapore.
FAU - Thalamuthu, Anbupalam
AU  - Thalamuthu A
FAU - Ong, Rick T H
AU  - Ong RT
FAU - Snippe, Harm
AU  - Snippe H
FAU - Boland, Greet J
AU  - Boland GJ
FAU - Seielstad, Mark
AU  - Seielstad M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110715
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - *Genome-Wide Association Study
MH  - HLA Antigens/*genetics/immunology
MH  - Hepatitis Antibodies/*immunology
MH  - Hepatitis B Vaccines/genetics/*immunology
MH  - Hepatitis B, Chronic/*genetics/*immunology/prevention & control
MH  - Humans
MH  - Indonesia
MH  - Polymorphism, Single Nucleotide
EDAT- 2011/07/19 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - ddr302 [pii]
AID - 10.1093/hmg/ddr302 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2011 Oct 1;20(19):3893-8. doi: 10.1093/hmg/ddr302. Epub 2011 Jul 
      15.