PMID- 21766199
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211020
IS  - 1573-6881 (Electronic)
IS  - 0145-479X (Linking)
VI  - 43
IP  - 4
DP  - 2011 Aug
TI  - Photosynthetic water oxidation vs. mitochondrial oxygen reduction: distinct 
      mechanistic parallels.
PG  - 437-46
LID - 10.1007/s10863-011-9370-7 [doi]
AB  - The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial 
      cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC 
      oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also 
      share a number of uncanny molecular and mechanistic similarities. Both feature a 
      redox-active polymetallic cluster that includes a key tyrosine, and both utilize 
      a two-phase mechanism. In one phase the polymetallic cluster undergoes four 
      sequential one-electron transfers: In the PSII-OEC, four successive 
      photooxidations of the photosystem II reaction center P680 (to P680(+)) allows 
      acceptance of 4 x 1e- from the Mn(4)Ca cluster; in CcO, four reduced cytochrome c 
      Fe(2+) cations donate 4 x 1e- to the bimetallic center. In the second phase for 
      each enzyme, the polymetallic cluster undergoes a single four-electron transfer 
      with the O(2)/2 H(2)O redox couple. Intriguing mechanistic similarities between 
      these two complex redox enzymes first delineated over a decade ago by 
      Hoganson/Proshlyakov/Babcock et al. are updated and expanded in this article.
FAU - Silverstein, Todd P
AU  - Silverstein TP
AD  - Chemistry Department, Willamette University, Salem, OR 97301, USA. 
      tsilvers@willamette.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 0 (Photosystem II Protein Complex)
RN  - 059QF0KO0R (Water)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Electron Transport Complex IV/chemistry/*metabolism
MH  - Mitochondria/*metabolism
MH  - Oxidation-Reduction
MH  - Photosynthesis
MH  - Photosystem II Protein Complex/chemistry/*metabolism
MH  - Water/chemistry/*metabolism
EDAT- 2011/07/19 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1007/s10863-011-9370-7 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 2011 Aug;43(4):437-46. doi: 10.1007/s10863-011-9370-7.