PMID- 21767075
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110823
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Aug
TI  - Six-minute walking distance in women with COPD.
PG  - 300-5
LID - 10.3109/15412555.2011.589870 [doi]
AB  - BACKGROUND: The 6-minute walk distance (6MWD) has been useful in the evaluation 
      of men with COPD. Little is known about 6MWD in women with the disease. 
      OBJECTIVES: Using healthy women as a reference, to evaluate the factors that help 
      determine 6MWD in women with COPD. To explore if the 350 meters threshold 
      differentiates survival in women as it does in men. METHODS: Healthy women (n = 
      164) and with COPD (n = 223) were included in the study. Age, pack-years history, 
      smoking status, comorbidities (Charlson Index), BMI, MRC dyspnea, spirometry and 
      6MWD were recorded in all participants and PaO(2) and IC/TLC in COPD women. The 
      patients were prospectively followed and deaths registered. Factors predicting 
      6MWD were determined by multiple regression analysis. ROC analysis was used to 
      calculate the best threshold value for the 6MWD with mortality as gold standard. 
      Kaplan-Meier curves compared survival of patients that walked more or less than 
      350 m by age categories. RESULTS: The 6MWD is decreased in women with COPD. 
      Values decrease with age and GOLD stages. Age, BMI, smoking status, 
      comorbidities, MRC and FEV(1%) are statistical significant predictors of 6MWD. A 
      350 m cut-off value has a good sensitivity and specificity to predict (73% and 
      80% respectively) and differentiate survival (p < 0.001 for log rank comparisons) 
      in these patients. CONCLUSIONS: In women with COPD, the 6MWD decreases with age 
      and GOLD stages. A 350 m distance is a valid threshold to differentiate survival. 
      Further studies in different settings should confirm our findings.
FAU - de Torres, Juan P
AU  - de Torres JP
AD  - Clinica Universidad de Navarra, Pamplona, Spain. jupa65@hotmail.com
FAU - Casanova, Ciro
AU  - Casanova C
FAU - Cote, Claudia G
AU  - Cote CG
FAU - Lopez, Maria V
AU  - Lopez MV
FAU - Diaz, Orlando
AU  - Diaz O
FAU - Maria Marin, Jose
AU  - Maria Marin J
FAU - Pinto-Plata, Victor
AU  - Pinto-Plata V
FAU - Montes de Oca, Maria
AU  - Montes de Oca M
FAU - Aguirre-Jaime, Armando
AU  - Aguirre-Jaime A
FAU - Celli, Bartolome R
AU  - Celli BR
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110718
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Body Mass Index
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/mortality/*physiopathology
MH  - ROC Curve
MH  - Regression Analysis
MH  - Respiratory Function Tests
MH  - Sensitivity and Specificity
MH  - Sex Factors
MH  - Smoking/adverse effects
MH  - Survival Rate
MH  - Walking/*physiology
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3109/15412555.2011.589870 [doi]
PST - ppublish
SO  - COPD. 2011 Aug;8(4):300-5. doi: 10.3109/15412555.2011.589870. Epub 2011 Jul 18.