PMID- 21767219
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 49
IP  - 10
DP  - 2011 Oct
TI  - Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell 
      lung cancer.
PG  - 1591-603
LID - 10.1515/CCLM.2011.661 [doi]
AB  - Non-small cell lung carcinomas (NSCLC) account for about 80% of lung cancers and 
      their remarkable heterogeneity manifests in histology, pathogenesis, prognosis, 
      and response to treatments. Recent advances in molecular characterization help 
      stratifying NSCLC patients for their potential benefit from targeting therapies. 
      However, the fundamental mechanisms underlying the tumoral heterogeneity remain 
      poorly understood. Expression profiling of many microRNAs (miRNAs) in various 
      normal and disease tissues demonstrated unique spatial and temporal expression 
      patterns and some miRNAs have been functionally characterized as oncogenes or 
      tumor suppressor genes. Genome-wide screening identified specific miRNA 
      expression signatures associated with clinical outcome of NSCLC patients. A group 
      of miRNAs that has enriched expression in normal lung was found down regulated in 
      NSCLC and may function as tumor suppressor genes. In this review we: a) summarize 
      the current understanding of the critical role that miRNAs play in normal cell 
      functions and in disease biology especially in lung cancer tumorigenesis, b) 
      highlight their potential as biomarkers for lung cancer risk stratification, 
      outcome prediction and classification of histologic subtypes, c) critically 
      assess current knowledge on lung-enriched miRNAs and expression of their 
      predicted target genes in NSCLC and d) evaluate their potential as circulating 
      biomarkers and therapeutic targets in lung cancer.
FAU - Markou, Athina
AU  - Markou A
AD  - Laboratory of Analytical Chemistry, Department of Chemistry, University of 
      Athens, Athens, Greece.
FAU - Liang, Yu
AU  - Liang Y
FAU - Lianidou, Evi
AU  - Lianidou E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110718
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (MicroRNAs)
SB  - IM
MH  - *Carcinoma, Non-Small-Cell Lung/diagnosis/genetics/therapy
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *Lung Neoplasms/diagnosis/genetics/therapy
MH  - *MicroRNAs/genetics/therapeutic use
MH  - Prognosis
EDAT- 2011/07/20 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1515/CCLM.2011.661 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2011 Oct;49(10):1591-603. doi: 10.1515/CCLM.2011.661. Epub 
      2011 Jul 18.