PMID- 21767674
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20160518
IS  - 1876-7737 (Electronic)
IS  - 1874-3919 (Linking)
VI  - 75
IP  - 1
DP  - 2011 Dec 10
TI  - Proteomic analysis of plasma samples from patients with acute myocardial 
      infarction identifies haptoglobin as a potential prognostic biomarker.
PG  - 229-36
LID - 10.1016/j.jprot.2011.06.028 [doi]
AB  - Prognosis of clinical outcome following myocardial infarction is variable and 
      difficult to predict. We have analyzed the plasma proteome of thirty patients 
      with acute myocardial infarction to search for new prognostic biomarkers. 
      Proteomic analyses of blood samples were performed by 2-D-DiGE after plasma 
      depletion of albumin and immunoglobulins G. New York Heart Association (NYHA) 
      class determined at 1-year follow-up was used to identify patients with heart 
      failure. Principal component analysis and hierarchical clustering of proteomic 
      data revealed that patients could be separated into 3 groups. The 22 
      differentially expressed proteins involved in this grouping were identified as 
      haptoglobin (Hp) and respective isoforms. The 3 groups of patients had distinct 
      Hp isoforms: patients from group 1 had the alpha1-alpha1, patients from group 2 the 
      alpha2-alpha1, and patients from group 3 the alpha2-alpha2 genotype. This classification was also 
      associated with different total plasma levels of Hp. The presence of the alpha2 
      genotype and low plasma levels of Hp was associated with a higher NYHA class and 
      therefore with a detrimental functional outcome after myocardial infarction. A 
      plasma level of Hp below 1.4g/L predicted the occurrence of heart failure (NYHA 
      2, 3, 4) at 1-year with 100% sensitivity.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Haas, Benjamin
AU  - Haas B
AD  - Laboratory of Cardiovascular Research, Centre de Recherche Public-Sante, 
      Luxembourg, Luxembourg.
FAU - Serchi, Tommaso
AU  - Serchi T
FAU - Wagner, Daniel R
AU  - Wagner DR
FAU - Gilson, Georges
AU  - Gilson G
FAU - Planchon, Sebastien
AU  - Planchon S
FAU - Renaut, Jenny
AU  - Renaut J
FAU - Hoffmann, Lucien
AU  - Hoffmann L
FAU - Bohn, Torsten
AU  - Bohn T
FAU - Devaux, Yvan
AU  - Devaux Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - Netherlands
TA  - J Proteomics
JT  - Journal of proteomics
JID - 101475056
RN  - 0 (Biomarkers)
RN  - 0 (Haptoglobins)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Acute Disease
MH  - Biomarkers/*analysis/blood
MH  - Haptoglobins/*analysis/genetics/metabolism
MH  - Heart Failure/metabolism/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/metabolism/*pathology
MH  - Prognosis
MH  - Protein Isoforms/analysis/genetics/metabolism
MH  - Proteomics/*methods
EDAT- 2011/07/20 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/03/24 00:00 [received]
PHST- 2011/06/09 00:00 [revised]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - S1874-3919(11)00285-5 [pii]
AID - 10.1016/j.jprot.2011.06.028 [doi]
PST - ppublish
SO  - J Proteomics. 2011 Dec 10;75(1):229-36. doi: 10.1016/j.jprot.2011.06.028. Epub 
      2011 Jul 13.