PMID- 21767864
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20220408
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 85
IP  - 3
DP  - 2011 Oct
TI  - Circulating levels of persistent organic pollutants associate in divergent ways 
      to fat mass measured by DXA in humans.
PG  - 335-43
LID - 10.1016/j.chemosphere.2011.06.095 [doi]
AB  - BACKGROUND: Environmental contaminants have recently been implicated in the 
      pathogenesis of obesity. OBJECTIVE: To explore relations between persistent 
      organic pollutants (POPs) and fat mass independently of body stature, using a 
      cross-sectional design. METHODS: In the Prospective Study of the Vasculature in 
      Uppsala Seniors (PIVUS), fat mass was determined in 70-year-old subjects (n=890) 
      by dual-energy X-ray absorptiometry (DXA). The plasma levels of 21 POPs 
      (including 16 PCB congeners, 3 OC pesticides, 1 BDE47, and 1 dioxin) were 
      measured by high resolution chromatography coupled with high resolution mass 
      spectrometry (HRGC/HRMS). RESULTS: Lipid-standardized plasma concentrations of 
      octachlorodibenzo-p-dioxin (OCDD), the PCBs 74, 99, 105 and 118, and the 
      pesticides HCB, TNK, and DDE were all positively related to fat mass 
      (p=0.03-0.0001). Subjects in the fifth quintile for PCB 105 showed a mean fat 
      mass that was 4.8 kg more than subjects in the first quintile. On the other hand, 
      the PCBs 156, 157, 169, 170, 180, 189, 194, 206, and 209 were negatively related 
      to fat mass (p=0.0001). For PCB 194, subjects in the fifth quintile showed a mean 
      fat mass that was 10.8 kg less than subjects in the first quintile. Following 
      adjustment for smoking, physical activity, education level, height, lean mass, 
      and gender, these results remained significant (p=0.01-0.0001) except for the 
      PCBs 74 and 99. For some PCBs, the associations vs. fat mass were more pronounced 
      in women than in men. CONCLUSION: Plasma concentrations of some pesticides are 
      positively related to fat mass, while divergent associations are seen for the 
      PCBs. These results implicate a complex role of POPs in obesity.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Ronn, Monika
AU  - Ronn M
AD  - Occupational and Environmental Medicine, Department of Medicine, Uppsala 
      University, and Department of Medicine, Uppsala University Hospital, Uppsala, 
      Sweden.
FAU - Lind, Lars
AU  - Lind L
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - Michaelsson, Karl
AU  - Michaelsson K
FAU - Lind, Pia Monica
AU  - Lind PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Organogold Compounds)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - YW59P10266 (octachlorodibenzo-4-dioxin)
SB  - IM
MH  - *Absorptiometry, Photon
MH  - Adipose Tissue/*chemistry
MH  - Aged
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Male
MH  - Organogold Compounds/blood
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/blood
MH  - Prospective Studies
EDAT- 2011/07/20 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/06/23 00:00 [revised]
PHST- 2011/06/25 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - S0045-6535(11)00753-3 [pii]
AID - 10.1016/j.chemosphere.2011.06.095 [doi]
PST - ppublish
SO  - Chemosphere. 2011 Oct;85(3):335-43. doi: 10.1016/j.chemosphere.2011.06.095. Epub 
      2011 Jul 20.