PMID- 21767890
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20161125
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 94
IP  - 2
DP  - 2011 Nov
TI  - Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness 
      in type 2 diabetes mellitus.
PG  - 236-41
LID - 10.1016/j.diabres.2011.06.021 [doi]
AB  - AIMS: Media calcification is a predictor of cardiovascular mortality in type 2 
      diabetes mellitus (T2DM). Undercarboxylation of some vitamin K-dependent 
      proteins, due to genetic polymorphisms of VKORC1, can lead to calcification. We 
      examined a potential association between VKORC1 -1639 G>A polymorphism and T2DM 
      and, also, the association of this polymorphism with carotid intima-media 
      thickness (cIMT). METHODS: VKORC1 -1639 G>A polymorphism was determined in 299 
      T2DM patients and 328 controls of Caucasian origin using PCR-RFLP. cIMT was 
      measured in a subgroup of 118 T2DM patients. RESULTS: The frequency of VKORC1 
      genotypes between diabetic and nondiabetic subjects differed significantly 
      (p=0.01). VKORC1 genotype was associated with T2DM in an adjusted model (OR 1.36, 
      p=0.009). A statistically significant difference was observed in the maximum 
      value of cIMT among different genotypes. VKORC1 -1639 G>A polymorphism was an 
      independent predictor of cIMT (p=0.029) after adjusting for established risk 
      factors. CONCLUSIONS: The association between VKORC1 -1639 G>A polymorphism and 
      risk of T2DM could be due to the higher prevalence of calcification in T2DM 
      patients. This is supported by the independent association between VKORC1 -1639 
      G>A polymorphism and maximum cIMT in T2DM patients which is likely due to 
      atherosclerosis characterized by increased calcification.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Tavridou, Anna
AU  - Tavridou A
AD  - Lab of Pharmacology, Medical School, Democritus University of Thrace, Dragana 
      Campus, 68100 Alexandroupolis, Greece. atavrid@med.duth.gr
FAU - Petridis, Ioannis
AU  - Petridis I
FAU - Vasileiadis, Michail
AU  - Vasileiadis M
FAU - Ragia, Georgia
AU  - Ragia G
FAU - Heliopoulos, Ioannis
AU  - Heliopoulos I
FAU - Vargemezis, Vassileios
AU  - Vargemezis V
FAU - Manolopoulos, Vangelis G
AU  - Manolopoulos VG
LA  - eng
PT  - Journal Article
DEP - 20110720
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.17.4.4 (VKORC1 protein, human)
RN  - EC 1.17.4.4 (Vitamin K Epoxide Reductases)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Carotid Arteries/*diagnostic imaging
MH  - Carotid Artery Diseases/diagnostic imaging/enzymology/*genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/complications/enzymology/*genetics
MH  - Diabetic Angiopathies/diagnostic imaging/enzymology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Greece
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Mixed Function Oxygenases/*genetics
MH  - Odds Ratio
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tunica Intima/*diagnostic imaging
MH  - Tunica Media/*diagnostic imaging
MH  - Ultrasonography
MH  - Vascular Calcification/diagnostic imaging/enzymology/*genetics
MH  - Vitamin K Epoxide Reductases
EDAT- 2011/07/20 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/03/18 00:00 [received]
PHST- 2011/06/16 00:00 [revised]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S0168-8227(11)00343-3 [pii]
AID - 10.1016/j.diabres.2011.06.021 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2011 Nov;94(2):236-41. doi: 
      10.1016/j.diabres.2011.06.021. Epub 2011 Jul 20.