PMID- 21768163
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20211020
IS  - 1535-3699 (Electronic)
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 236
IP  - 9
DP  - 2011 Sep
TI  - Mechanisms maintaining genomic integrity in embryonic stem cells and induced 
      pluripotent stem cells.
PG  - 987-96
LID - 10.1258/ebm.2011.011107 [doi]
AB  - Embryonic stem cells (ESCs) are pluripotent, self-renewing cells that are 
      isolated during the blastocyst stage of embryonic development. Whether these 
      cells are derived from humans, mice or other organisms, all ESCs must employ 
      mechanisms that prevent the propagation of mutations, generated as a consequence 
      of DNA damage, to somatic cells produced by normal programmed differentiation. 
      Thus, the prevention of mutations in ESCs is important not only for the health of 
      the individual organism derived from these cells but also, in addition, for the 
      continued survival and genetic viability of the species by preventing the 
      accumulation of mutations in the germline. Induced pluripotent stem cells (IPSCs) 
      are reprogrammed somatic cells that share several characteristics with ESCs, 
      including a similar morphology in culture, the re-expression of pluripotency 
      markers and the ability to differentiate into defined cell lineages. This review 
      focuses on the mechanisms employed by murine ESCs, human ESCs and, where data are 
      available, IPSCs to preserve genetic integrity.
FAU - Tichy, Elisia D
AU  - Tichy ED
AD  - Department of Molecular Genetics, University of Cincinnati College of Medicine, 
      231 Albert Sabin Way, Cincinnati, OH 45267-0524, USA. tichyed@ucmail.uc.edu
LA  - eng
GR  - R01 ES012695/ES/NIEHS NIH HHS/United States
GR  - T32 ES007250/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110718
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Animals
MH  - Cell Cycle/genetics
MH  - DNA Damage/genetics
MH  - DNA Mismatch Repair/genetics
MH  - DNA Repair/*genetics/physiology
MH  - Embryonic Stem Cells/*metabolism
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*metabolism
MH  - Mice
MH  - Mutation/genetics
MH  - Oxidative Stress/genetics
MH  - Tumor Suppressor Protein p53/genetics
PMC - PMC4077782
MID - NIHMS591783
EDAT- 2011/07/20 06:00
MHDA- 2011/11/04 06:00
PMCR- 2014/07/01
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - ebm.2011.011107 [pii]
AID - 10.1258/ebm.2011.011107 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2011 Sep;236(9):987-96. doi: 10.1258/ebm.2011.011107. 
      Epub 2011 Jul 18.