PMID- 2176900
OWN - NLM
STAT- MEDLINE
DCOM- 19910226
LR  - 20190903
IS  - 0006-5242 (Print)
IS  - 0006-5242 (Linking)
VI  - 61
IP  - 5
DP  - 1990 Nov
TI  - Inhibition of coagulation and platelet adhesion to extracellular matrix by 
      unfractionated heparin and a low molecular weight heparin.
PG  - 289-94
AB  - In 7 healthy volunteers, the effect of a single i.v. injection of 52 mg (7,500 
      IU) of an unfractionated heparin (UFH) and of 52.5 mg (5,000 anti XaU) of a low 
      molecular weight heparin (LMWH) on coagulation parameters and platelet function 
      has been studied. Thrombin-induced platelet aggregation was inhibited after the 
      injection of both heparins. There was no significant change of ADP or 
      collagen-induced aggregation after LMWH of UFH. Platelet adhesion to bovine 
      extracellular matrix was not inhibited by UFH but was significantly reduced after 
      addition in vitro and ex vivo after administration of LMWH. Further investigation 
      should establish the time course of LMWH effects on platelet adhesion. A long 
      duration of this effect could be partially correlated with the antithrombotic 
      effects of LMWH.
FAU - Krupinski, K
AU  - Krupinski K
AD  - Department of Hematology, Medical School, Bialystok, Poland.
FAU - Basic-Micic, M
AU  - Basic-Micic M
FAU - Lindhoff, E
AU  - Lindhoff E
FAU - Breddin, H K
AU  - Breddin HK
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Blut
JT  - Blut
JID - 0173401
RN  - 0 (Anticoagulants)
RN  - 0 (Glycoproteins)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Protein S)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/pharmacology
MH  - Blood Coagulation/*drug effects
MH  - Extracellular Matrix/*drug effects
MH  - Female
MH  - Glycoproteins/*deficiency
MH  - Heparin/*pharmacology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Humans
MH  - Male
MH  - Platelet Adhesiveness/*drug effects
MH  - Platelet Aggregation/drug effects
MH  - Platelet Aggregation Inhibitors/pharmacology
MH  - Protein S
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - 10.1007/BF01732879 [doi]
PST - ppublish
SO  - Blut. 1990 Nov;61(5):289-94. doi: 10.1007/BF01732879.