PMID- 21770738
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20190816
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Mar
TI  - Do FY antigens act as minor histocompatibility antigens in the graft-versus-host 
      disease paradigm after human leukocyte antigen-identical sibling hematopoietic 
      stem cell transplantation?
PG  - 331-6
LID - 10.1089/dna.2011.1321 [doi]
AB  - FY antigens are candidate minor histocompatibility antigens relevant to renal 
      allograft rejection, but no data have been reported about their role in 
      graft-versus-host disease (GVHD) incidence after human leukocyte antigen 
      (HLA)-identical siblings hematopoietic stem cell transplantation (HSCT). The aim 
      of this study was to examine the effect of donor/recipient disparity at FY 
      antigens on the incidence of GVHD in Tunisian patients receiving an HLA-identical 
      HSCT. This work enrolled 105 Tunisian pairs of recipients and their HLA-identical 
      sibling donors of HSCs. FY genotyping was performed with the polymerase chain 
      reaction-sequence-specific primer method and donor/recipient disparity for these 
      antigens was analyzed at two levels: incompatibility and nonidentity. The 
      case-control analyses showed no significant correlation between FY disparity and 
      the incidence of either acute or chronic GVHD. Sample size calculation showed 
      that 572 cases and 1716 controls would be necessary to be able to detect a 
      significant association with 80% power and two-sided type I error level of 5% 
      (alpha=0.05). The lack of association in the studied cohort may be explained by the 
      low immunogenicity of FY antigens in HSCT context, compared with other antigens 
      such as HA-1 and CD31.
FAU - Sellami, Mohamed Hichem
AU  - Sellami MH
AD  - The Immunogenetic Applied to Cells Therapy Research Unit, The Immunohaematology 
      and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, 
      Tunisia. sellamimh@laposte.net
FAU - Chaabane, Manel
AU  - Chaabane M
FAU - Kaabi, Houda
AU  - Kaabi H
FAU - Torjemane, Lamia
AU  - Torjemane L
FAU - Ladeb, Saloua
AU  - Ladeb S
FAU - Ben Othmane, Tarek
AU  - Ben Othmane T
FAU - Hmida, Slama
AU  - Hmida S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (ACKR1 protein, human)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Acute Disease
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Duffy Blood-Group System/*immunology
MH  - Female
MH  - Graft vs Host Disease/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens/*immunology
MH  - Humans
MH  - Leukocytes/*immunology
MH  - Male
MH  - Receptors, Cell Surface/*immunology
MH  - *Siblings
EDAT- 2011/07/21 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1089/dna.2011.1321 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2012 Mar;31(3):331-6. doi: 10.1089/dna.2011.1321. Epub 2011 Jul 
      19.