PMID- 21771100
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20220311
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 20
IP  - 10
DP  - 2011 Oct
TI  - Itch-associated scratching contributes to the development of dermatitis and 
      hyperimmunoglobulinaemia E in NC/Nga mice.
PG  - 820-5
LID - 10.1111/j.1600-0625.2011.01337.x [doi]
AB  - Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a 
      type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the 
      aetiology. While itching and scratching are important factors in the development 
      of dermatitis, the mechanisms underlying these phenomena are poorly understood. 
      We investigated the relationship between scratching, transepidermal water loss 
      (TEWL), signs of dermatitis and serum Ig levels in NC/Nga mice, a model of AD. We 
      also sensitized specific pathogen-free (SPF)-NC/Nga mice and BALB/c mice to mite 
      antigen to determine the effects of IgE overproduction on scratching and 
      investigated the involvement of mast cells and T/B cells in the induction of 
      scratching using WBB6F1-W/W(v) mice and C.B.17/Icr-scid mice. Under conventional 
      conditions, the scratch counts increased, followed by increases in TEWL and the 
      inflammation score in NC/Nga mice that were not kept under SPF conditions. 
      However, no change was observed in scratching, TEWL, or signs of dermatitis in 
      mite antigen-sensitized SPF-NC/Nga and BALB/c mice, although the serum total IgE, 
      IgG(1) and IgG(2a) levels increased. The scratch count increased significantly in 
      both the WBB6F1-W/W(v) mice and C.B.17/Icr-scid mice when they were co-housed 
      with skin-lesioned NC/Nga mice, raised under conventional conditions. These 
      results show that IgE overproduction results from itch-associated 
      scratching-induced dermatitis in NC/Nga mice.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Hashimoto, Yuki
AU  - Hashimoto Y
AD  - Department of Pharmacology, Medicinal Research Laboratories, Taisho 
      Pharmaceutical Co. Ltd, Kita-ku, Saitama, Japan.
FAU - Takaoka, Akiko
AU  - Takaoka A
FAU - Sugimoto, Masanori
AU  - Sugimoto M
FAU - Honma, Yusuke
AU  - Honma Y
FAU - Sakurai, Takanobu
AU  - Sakurai T
FAU - Futaki, Nobuko
AU  - Futaki N
FAU - Arai, Iwao
AU  - Arai I
LA  - eng
PT  - Journal Article
DEP - 20110719
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/administration & dosage
MH  - Animals
MH  - Antigens, Dermatophagoides/administration & dosage
MH  - Dermatitis, Atopic/*etiology/*immunology/pathology
MH  - Disease Models, Animal
MH  - Hypergammaglobulinemia/*etiology/*immunology
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, SCID
MH  - Pruritus/*complications
MH  - Skin/immunology/pathology
MH  - Specific Pathogen-Free Organisms
EDAT- 2011/07/21 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1111/j.1600-0625.2011.01337.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2011 Oct;20(10):820-5. doi: 10.1111/j.1600-0625.2011.01337.x. Epub 
      2011 Jul 19.