PMID- 21771286
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20160511
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 59
IP  - 1
DP  - 2012 Feb
TI  - Epidemiologic and phylogenetic characteristics of porcine reproductive and 
      respiratory syndrome viruses in conventional swine farms of Jeju Island as a 
      candidate region for PRRSV eradication.
PG  - 62-71
LID - 10.1111/j.1865-1682.2011.01243.x [doi]
AB  - Jeju island is the biggest island in Korea. The imports of pigs or their 
      relatives from mainland Korea to this island has been banned since 1998. With 
      this unique geographical and epidemiological context, epidemiology of porcine 
      reproductive and respiratory syndrome virus (PRRSV) was investigated on the 
      island. While all investigated farms showed 100% of seropositive rate for PRRSV, 
      pigs on 37.2% (16/43) of the farms had viremia with type II PRRSV. The 
      seropositive and viremia-positive rates for PRRSV in 30- to 60-day-old pigs were 
      significantly higher in the western area ('swine farm complex' area) than the 
      eastern area ('Scattered swine farm' area) of Jeju island. When 21 ORF5 sequences 
      obtained from viremic sera were phylogenetically analysed, lineage 5 and Kor 
      (newly termed in this study) of type II PRRSV were only found in Jeju island 
      without changes from a previous report (2002-2003). Because other lineages of 
      type II PRRSV (lineage 1 and 3) and type I PRRSV have recently emerged in 
      mainland Korea, the banning of pigs' movement might be effective to protect the 
      island from the introduction of these new PRRSV genotypes. Under this 
      epidemiological condition (no introduction of new strains except for the 
      modified-live vaccine (MLV) strain), the positive selection sites were analysed 
      based on ORF5 of the virus. The amino acid 58 of GP5 (located on the 
      hypervariable region) was predicted as a strong positive selection site. Although 
      51.2% (22/43) of the investigated farms had applied MLV, field strains of type II 
      PRRSV were still circulating with strong positive selection. However, the 
      restricted population of type II PRRSV (lineage 5 and Kor) without introduction 
      of type I PRRSV or the other lineages of type II PRRSV indicate that the island 
      has an effective quarantine system, which would allow PRRSV eradication.
CI  - (c) 2011 Blackwell Verlag GmbH.
FAU - Kim, H K
AU  - Kim HK
AD  - Department of Veterinary Virology, College of Veterinary Medicine and BK21 
      Program for Veterinary Science, Seoul National University, Seoul, Korea
FAU - Nguyen, V G
AU  - Nguyen VG
FAU - Kim, I O
AU  - Kim IO
FAU - Park, J H
AU  - Park JH
FAU - Park, S J
AU  - Park SJ
FAU - Rho, S M
AU  - Rho SM
FAU - Han, J Y
AU  - Han JY
FAU - Park, B K
AU  - Park BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animal Husbandry
MH  - Animals
MH  - Databases, Nucleic Acid
MH  - Genotype
MH  - Open Reading Frames/genetics
MH  - Phylogeny
MH  - Polymerase Chain Reaction/veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/blood/*epidemiology/prevention & 
      control
MH  - Porcine respiratory and reproductive syndrome virus/*genetics/isolation & 
      purification
MH  - Republic of Korea/epidemiology
MH  - Swine
MH  - Viral Vaccines/therapeutic use
EDAT- 2011/07/21 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1111/j.1865-1682.2011.01243.x [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2012 Feb;59(1):62-71. doi: 
      10.1111/j.1865-1682.2011.01243.x. Epub 2011 Jul 19.