PMID- 21771643
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20210816
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 206
IP  - 2
DP  - 2011 Oct 10
TI  - Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA 
      expression in human breast cancer cells via an estrogen receptor alpha-dependent 
      mechanism.
PG  - 152-7
LID - 10.1016/j.toxlet.2011.07.007 [doi]
AB  - Environmental chemicals with estrogenic activity, known as xenoestrogens, may 
      cause impaired reproductive development and endocrine-related cancers in humans 
      by disrupting endocrine functions. Aryl-hydrocarbon receptor nuclear translocator 
      2 (ARNT2) is believed to play important roles in a variety of physiological 
      processes, including estrogen signaling pathways, that may be involved in the 
      pathogenesis and therapeutic responses of endocrine-related cancers. However, 
      much of the underlying mechanism remains unknown. In this study, we investigated 
      whether ARNT2 expression is regulated by a range of representative xenoestrogens 
      in human cancer cell lines. Bisphenol A (BPA), benzyl butyl phthalate (BBP), and 
      1,1,1-trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p'-DDT) were 
      found to be estrogenic toward BG1Luc4E2 cells by an E-CALUX bioassay. ARNT2 
      expression was downregulated by BPA, BBP, and o,p'-DDT in a dose-dependent manner 
      in estrogen receptor 1 (ESR1)-positive MCF-7 and BG1Luc4E2 cells, but not in 
      estrogen receptor-negative LNCaP cells. The reduction in ARNT2 expression in 
      cells treated with the xenoestrogens was fully recovered by the addition of a 
      specific ESR1 antagonist, MPP. In conclusion, we have shown for the first time 
      that ARNT2 expression is modulated by xenoestrogens by an ESR1-dependent 
      mechanism in MCF-7 breast cancer cells.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Qin, Xian-Yang
AU  - Qin XY
AD  - Research Center for Environmental Risk, National Institute for Environmental 
      Studies, 16-2 Onogawa, Tsukuba, Japan.
FAU - Zaha, Hiroko
AU  - Zaha H
FAU - Nagano, Reiko
AU  - Nagano R
FAU - Yoshinaga, Jun
AU  - Yoshinaga J
FAU - Yonemoto, Junzo
AU  - Yonemoto J
FAU - Sone, Hideko
AU  - Sone H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110712
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 
      (1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole)
RN  - 0 (ARNT2 protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (ESR1 protein, human)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 0 (RNA, Messenger)
RN  - 0 (Xenobiotics)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
RN  - CIW5S16655 (DDT)
RN  - D4K93Z1TBH (o,p'-DDT)
RN  - MLT3645I99 (bisphenol A)
RN  - YPC4PJX59M (butylbenzyl phthalate)
SB  - IM
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator/genetics/*metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/genetics/*metabolism
MH  - Benzhydryl Compounds
MH  - Breast Neoplasms/*metabolism
MH  - Cell Line, Tumor
MH  - DDT/pharmacology
MH  - Down-Regulation/*drug effects
MH  - Endocrine Disruptors/*pharmacology
MH  - Estrogen Receptor alpha/antagonists & inhibitors/genetics/*metabolism
MH  - Estrogens, Non-Steroidal/*pharmacology
MH  - Female
MH  - Genes, Reporter/drug effects
MH  - Humans
MH  - Neoplasm Proteins/antagonists & inhibitors/genetics/metabolism
MH  - Osmolar Concentration
MH  - Ovarian Neoplasms/metabolism
MH  - Phenols/pharmacology
MH  - Phthalic Acids/pharmacology
MH  - Piperidines/pharmacology
MH  - Pyrazoles/pharmacology
MH  - RNA, Messenger/metabolism
MH  - Response Elements/drug effects
MH  - Xenobiotics/*pharmacology
EDAT- 2011/07/21 06:00
MHDA- 2011/10/22 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/01/20 00:00 [received]
PHST- 2011/07/01 00:00 [revised]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
AID - S0378-4274(11)01420-2 [pii]
AID - 10.1016/j.toxlet.2011.07.007 [doi]
PST - ppublish
SO  - Toxicol Lett. 2011 Oct 10;206(2):152-7. doi: 10.1016/j.toxlet.2011.07.007. Epub 
      2011 Jul 12.